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CG8858 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36319, updated on 9-Dec-2024

Summary

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Official Symbol
CG8858provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033698
Locus tag
Dmel_CG8858
See related
AllianceGenome:FB:FBgn0033698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8858
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in ERAD pathway. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and spermatozoon. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG8858 in Genome Data Viewer
Location:
48E8-48E8; 2-66 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12192374..12198854, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8079879..8086359, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Small ribonucleoprotein particle protein SmF Neighboring gene Cytochrome P450 6g1 Neighboring gene Cytochrome P450 6g2 Neighboring gene Cytochrome P450 6t3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226
  2. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
  3. Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. Mu Y, et al. J Biol Chem, 2019 Aug 30. PMID 31324721, Free PMC Article
  4. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. Ou Q, et al. PLoS Biol, 2011 Sep. PMID 21980261, Free PMC Article
  5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8858-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12192374..12198854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136902.3 → NP_610746.1  uncharacterized protein Dmel_CG8858 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K1A6, Q9V677
    Related
    FBpp0087116
    Conserved Domains (2) summary
    pfam13001
    Location:20 → 504
    Ecm29; Proteasome stabilizer
    sd00044
    Location:1502 → 1535
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V677.1 Q9V677

Gene LinkOut

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