Tmem14a transmembrane protein 14A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tmem14aprovided by RGD
Full Name: transmembrane protein 14Aprovided by RGD
Primary source: RGD:1307710
See related: EnsemblRapid:ENSRNOG00000013238 AllianceGenome:RGD:1307710
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and regulation of heme biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial membrane. Orthologous to human TMEM14A (transmembrane protein 14A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 146.7), Adrenal (RPKM 104.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (31137011..31148794)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (23640594..23652379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (27333956..27345612)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transmembrane protein 14A protects glomerular filtration barrier integrity.
Title: Transmembrane protein 14A protects glomerular filtration barrier integrity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 14A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.