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Mitd1 microtubule interacting and trafficking domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363219, updated on 27-Nov-2024

Summary

Official Symbol
Mitd1provided by RGD
Official Full Name
microtubule interacting and trafficking domain containing 1provided by RGD
Primary source
RGD:1307700
See related
EnsemblRapid:ENSRNOG00000018467 AllianceGenome:RGD:1307700
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307700
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein domain specific binding activity. Predicted to be involved in midbody abscission. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to colocalize with midbody. Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 96.4), Spleen (RPKM 73.7) and 9 other tissues See more
Orthologs
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Genomic context

See Mitd1 in Genome Data Viewer
Location:
9q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47609743..47621033, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40113943..40125280, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44472364..44483723, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene chromosome 9 C2orf15 homolog Neighboring gene lipoyltransferase 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC109091

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in midbody abscission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MIT domain-containing protein 1
Names
MIT, microtubule interacting and transport, domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009714.1NP_001009714.1  MIT domain-containing protein 1

    See identical proteins and their annotated locations for NP_001009714.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088263
    UniProtKB/Swiss-Prot
    Q5I0J5
    UniProtKB/TrEMBL
    A6INI5
    Related
    ENSRNOP00000024959.6, ENSRNOT00000024959.9
    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    cd02685
    Location:97245
    MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    47609743..47621033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083841.2XP_038939769.1  MIT domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    cl02780
    Location:97216
    MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.
  2. XM_006244828.5XP_006244890.1  MIT domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    pfam16565
    Location:100230
    MIT_C; Phospholipase D-like domain at C-terminus of MIT
  3. XM_008767036.4XP_008765258.1  MIT domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    cl02780
    Location:100198
    MIT_C; MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.