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Prss56 serine protease 56 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363274, updated on 9-Dec-2024

Summary

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Official Symbol
Prss56provided by RGD
Official Full Name
serine protease 56provided by RGD
Primary source
RGD:1563955
See related
EnsemblRapid:ENSRNOG00000029865 AllianceGenome:RGD:1563955
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563955
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation; positive regulation of leukocyte chemotaxis; and proteolysis. Predicted to act upstream of or within camera-type eye development. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in isolated microphthalmia 6. Orthologous to human PRSS56 (serine protease 56). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 4.4), Heart (RPKM 1.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prss56 in Genome Data Viewer
Location:
9q35
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95289984..95307877)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87842806..87859978)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94278981..94284111)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase 3, intestine, not Mn requiring Neighboring gene endothelin converting enzyme-like 1 Neighboring gene uncharacterized LOC134480403 Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene cholinergic receptor nicotinic gamma subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes. Wittmann G, et al. J Comp Neurol, 2018 Oct 15. PMID 30242838, Free PMC Article
  2. Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease. Gal A, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397065, Free PMC Article
  3. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nair KS, et al. Nat Genet, 2011 Jun. PMID 21532570, Free PMC Article
  4. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the variable, inversely correlating expression of Prss56 and Pomc reflect periodically oscillating gene expression in tanycytes rather than stable expression levels that vary between individual rats
    Title: Prss56 expression in the rodent hypothalamus: Inverse correlation with pro-opiomelanocortin suggests oscillatory gene expression in adult rat tanycytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PRSS56 protease, serine, 56; serine protease 56
Names
protease, serine, 56

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    95289984..95307877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267933.1 → XP_063124003.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  2. XM_063267924.1 → XP_063123994.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  3. XM_063267929.1 → XP_063123999.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  4. XM_063267931.1 → XP_063124001.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  5. XM_063267922.1 → XP_063123992.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  6. XM_063267921.1 → XP_063123991.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  7. XM_063267923.1 → XP_063123993.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  8. XM_063267928.1 → XP_063123998.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  9. XM_063267919.1 → XP_063123989.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  10. XM_063267932.1 → XP_063124002.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  11. XM_063267925.1 → XP_063123995.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  12. XM_063267926.1 → XP_063123996.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  13. XM_063267930.1 → XP_063124000.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  14. XM_039084699.2 → XP_038940627.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8
    Related
    ENSRNOP00000082562.1, ENSRNOT00000095059.2
    Conserved Domains (1) summary
    cd00190
    Location:112 → 342
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  15. XM_063267917.1 → XP_063123987.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  16. XM_063267927.1 → XP_063123997.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

  17. XM_063267918.1 → XP_063123988.1  serine protease 56

    UniProtKB/TrEMBL
    A0A8I6G9L9, D3ZQJ8

RNA

  1. XR_010054851.1 RNA Sequence

  2. XR_010054852.1 RNA Sequence

  3. XR_005489287.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134586.1: Suppressed sequence

    Description
    NM_001134586.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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