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Stap2 signal transducing adaptor family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363334, updated on 4-Jan-2025

Summary

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Official Symbol
Stap2provided by RGD
Official Full Name
signal transducing adaptor family member 2provided by RGD
Primary source
RGD:1566020
See related
EnsemblRapid:ENSRNOG00000047306 AllianceGenome:RGD:1566020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling adaptor activity. Predicted to be located in plasma membrane. Orthologous to human STAP2 (signal transducing adaptor family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 137.0), Lung (RPKM 58.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stap2 in Genome Data Viewer
Location:
9q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (915546..924604, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (828369..838648, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11064605..11070138)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene MPN domain containing Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene chromatin assembly factor 1 subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. Minoguchi M, et al. J Biol Chem, 2003 Mar 28. PMID 12540842
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108972

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal-transducing adaptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025026.2 → NP_001020197.1  signal-transducing adaptor protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001020197.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887, Q5BK28
    Related
    ENSRNOP00000065679.2, ENSRNOT00000075121.4
    Conserved Domains (2) summary
    cd10404
    Location:151 → 247
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:9 → 135
    PH-like; Pleckstrin homology-like domain

  2. NM_001432963.1 → NP_001419892.1  signal-transducing adaptor protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887

  3. NM_001432964.1 → NP_001419893.1  signal-transducing adaptor protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887

  4. NM_001432965.1 → NP_001419894.1  signal-transducing adaptor protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887

  5. NM_001432966.1 → NP_001419895.1  signal-transducing adaptor protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887

  6. NM_001432967.1 → NP_001419896.1  signal-transducing adaptor protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R887

  7. NM_001432968.1 → NP_001419897.1  signal-transducing adaptor protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  8. NM_001432969.1 → NP_001419898.1  signal-transducing adaptor protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    915546..924604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083945.2 → XP_038939873.1  signal-transducing adaptor protein 2 isoform X4

    UniProtKB/TrEMBL
    M0R887
    Conserved Domains (2) summary
    cd10404
    Location:88 → 184
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:11 → 72
    PH-like; Pleckstrin homology-like domain

  2. XM_063267487.1 → XP_063123557.1  signal-transducing adaptor protein 2 isoform X8

  3. XM_063267484.1 → XP_063123554.1  signal-transducing adaptor protein 2 isoform X5

  4. XM_039083944.2 → XP_038939872.1  signal-transducing adaptor protein 2 isoform X2

    Related
    ENSRNOP00000111439.1, ENSRNOT00000167203.1
    Conserved Domains (2) summary
    cd10404
    Location:112 → 208
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:11 → 96
    PH-like; Pleckstrin homology-like domain

  5. XM_063267485.1 → XP_063123555.1  signal-transducing adaptor protein 2 isoform X6

  6. XM_063267483.1 → XP_063123553.1  signal-transducing adaptor protein 2 isoform X3

  7. XM_039083943.2 → XP_038939871.1  signal-transducing adaptor protein 2 isoform X1

    Related
    ENSRNOP00000078687.2, ENSRNOT00000101244.2
    Conserved Domains (2) summary
    cd10404
    Location:153 → 249
    SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
    cl17171
    Location:11 → 137
    PH-like; Pleckstrin homology-like domain

  8. XM_063267486.1 → XP_063123556.1  signal-transducing adaptor protein 2 isoform X7

    UniProtKB/TrEMBL
    A6KR17

  9. XM_063267488.1 → XP_063123558.1  signal-transducing adaptor protein 2 isoform X9

  10. XM_063267489.1 → XP_063123559.1  signal-transducing adaptor protein 2 isoform X10

RNA

  1. XR_010054617.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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