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Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363450, updated on 27-Nov-2024

Summary

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Official Symbol
Ftsj1provided by RGD
Official Full Name
FtsJ RNA 2'-O-methyltransferase 1provided by RGD
Primary source
RGD:1561061
See related
EnsemblRapid:ENSRNOG00000004776 AllianceGenome:RGD:1561061
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561061
Summary
Predicted to enable S-adenosyl-L-methionine binding activity and tRNA methyltransferase activity. Predicted to be involved in cytoplasmic translation; neurogenesis; and wobble position ribose methylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 29.9), Spleen (RPKM 26.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ftsj1 in Genome Data Viewer
Location:
Xq12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16915087..16929426)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14243684..14256555)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (14993685..15006010)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 5 Neighboring gene ribosomal protein L29, pseudogene 21 Neighboring gene uncharacterized LOC134484175 Neighboring gene porcupine O-acyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Guy MP, et al. Hum Mutat, 2015 Dec. PMID 26310293, Free PMC Article
  2. Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. Guy MP, et al. RNA, 2015 Jan. PMID 25404562, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (guanine) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA 2'-O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA nucleoside ribose methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in wobble position ribose methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Names
FtsJ RNA methyltransferase homolog 1
Ftsj homolog 1
putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
NP_001388094.1
NP_001388095.1
XP_006256811.1
XP_006256812.1
XP_008771308.1
XP_008771309.1
XP_008771310.1
XP_008771313.1
XP_038956390.1
XP_038956393.1
XP_038956394.1
XP_038956395.1
XP_063136187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401165.1 → NP_001388094.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000021

  2. NM_001401166.1 → NP_001388095.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000021
    Related
    ENSRNOP00000088344.1, ENSRNOT00000100380.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    16915087..16929426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773086.4 → XP_008771308.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008771308.1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Related
    ENSRNOP00000006365.7, ENSRNOT00000006365.8
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  2. XM_008773088.4 → XP_008771310.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008771310.1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  3. XM_063280117.1 → XP_063136187.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X2

  4. XM_008773091.4 → XP_008771313.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_008771313.1

    UniProtKB/TrEMBL
    A0A8I6A982
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  5. XM_006256750.5 → XP_006256812.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006256812.1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  6. XM_006256749.5 → XP_006256811.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006256811.1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Related
    ENSRNOP00000110433.1, ENSRNOT00000162482.1
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  7. XM_008773087.4 → XP_008771309.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008771309.1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  8. XM_039100465.2 → XP_038956393.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X4

    UniProtKB/TrEMBL
    A0A8I6A982
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  9. XM_039100462.2 → XP_038956390.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A982, D3ZZA1
    Conserved Domains (1) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  10. XM_039100466.2 → XP_038956394.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X5

    Conserved Domains (1) summary
    COG0293
    Location:1 → 125
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

  11. XM_039100467.2 → XP_038956395.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X6

    UniProtKB/TrEMBL
    A6KP37
    Conserved Domains (1) summary
    pfam01728
    Location:7 → 88
    FtsJ; FtsJ-like methyltransferase
Nucleotide Protein Strain
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