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Apoo apolipoprotein O [ Rattus norvegicus (Norway rat) ]

Gene ID: 363474, updated on 27-Nov-2024

Summary

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Official Symbol
Apooprovided by RGD
Official Full Name
apolipoprotein Oprovided by RGD
Primary source
RGD:1565289
See related
EnsemblRapid:ENSRNOG00000046918 AllianceGenome:RGD:1565289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565289
Summary
Predicted to be involved in cristae formation. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human APOO (apolipoprotein O). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 280.3), Muscle (RPKM 213.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Apoo in Genome Data Viewer
Location:
Xq22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (63151736..63256696)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (59157971..59262940)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63521033..63625134)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 21, pseudogene 1 Neighboring gene similar to human chromosome X open reading frame 58 Neighboring gene RWD domain containing 4, pseudogene 1 Neighboring gene uncharacterized LOC108349225 Neighboring gene small nucleolar RNA, H/ACA box 11E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. Turkieh A, et al. J Clin Invest, 2014 May. PMID 24743151, Free PMC Article
  2. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. Koob S, et al. Biochim Biophys Acta, 2015 Jul. PMID 25764979
  3. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, et al. Biol Chem, 2012 Nov. PMID 23109542
  4. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. Ott C, et al. PLoS One, 2015. PMID 25781180, Free PMC Article
  5. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit MIC26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199178.1 → NP_001186107.1  MICOS complex subunit MIC26

    Status: VALIDATED

    Source sequence(s)
    CB616794, DV726817, FM122174
    UniProtKB/TrEMBL
    A0A8I6A768, M0R7V3
    Related
    ENSRNOP00000065539.2, ENSRNOT00000071590.5
    Conserved Domains (1) summary
    pfam09769
    Location:41 → 177
    ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    63151736..63256696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099894.2 → XP_038955822.1  MICOS complex subunit MIC26 isoform X2

    Conserved Domains (1) summary
    pfam09769
    Location:54 → 80
    ApoO; Apolipoprotein O

  2. XM_039099895.1 → XP_038955823.1  MICOS complex subunit MIC26 isoform X3

    Conserved Domains (1) summary
    pfam09769
    Location:54 → 86
    ApoO; Apolipoprotein O

  3. XM_039099893.2 → XP_038955821.1  MICOS complex subunit MIC26 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A768, A6IQ10
    Related
    ENSRNOP00000089406.2, ENSRNOT00000098632.2
    Conserved Domains (1) summary
    pfam09769
    Location:20 → 143
    ApoO; Apolipoprotein O
Nucleotide Protein Strain
Heading Accession and Version

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