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Cpr49Ac Cuticular protein 49Ac [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36348, updated on 4-Jan-2025

Summary

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Official Symbol
Cpr49Acprovided by FlyBase
Official Full Name
Cuticular protein 49Acprovided by FlyBase
Primary source
FLYBASE:FBgn0033725
Locus tag
Dmel_CG8502
See related
AllianceGenome:FB:FBgn0033725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8502; Dmel\CG8502
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in extracellular region. Is expressed in several structures, including dorsal ectoderm anlage; embryonic foregut sensory structure; embryonic/larval fat body; eye disc posterior to the morphogenetic furrow; and imaginal disc. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cpr49Ac in Genome Data Viewer
Location:
49A1-49A2; 2-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12386666..12390057)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8274171..8277562)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 49Ad Neighboring gene Odorant receptor 49a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. Slaidina M, et al. Genes Dev, 2020 Feb 1. PMID 31919193, Free PMC Article
  2. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
  3. Mud Loss Restricts Yki-Dependent Hyperplasia in Drosophila Epithelia. Parra AS, et al. J Dev Biol, 2020 Dec 13. PMID 33322177, Free PMC Article
  4. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
  5. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Weake VM, et al. EMBO J, 2008 Jan 23. PMID 18188155, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chitin-based larval cuticle ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chitin-based extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
cuticular protein 49Ac
Names
CG8502-PA
CG8502-PC
CG8502-PD
CG8502-PE
CG8502-PF
CG8502-PG
Cpr49Ac-PA
Cpr49Ac-PC
Cpr49Ac-PD
Cpr49Ac-PE
Cpr49Ac-PF
Cpr49Ac-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12386666..12390057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299417.1 → NP_001286346.1  cuticular protein 49Ac, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286346.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG85
    Conserved Domains (1) summary
    pfam00379
    Location:166 → 217
    Chitin_bind_4; Insect cuticle protein

  2. NM_165892.4 → NP_725150.2  cuticular protein 49Ac, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725150.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR69
    Related
    FBpp0087027
    Conserved Domains (1) summary
    pfam00379
    Location:175 → 226
    Chitin_bind_4; Insect cuticle protein

  3. NM_001299416.1 → NP_001286345.1  cuticular protein 49Ac, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286345.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG85
    Conserved Domains (1) summary
    pfam00379
    Location:166 → 217
    Chitin_bind_4; Insect cuticle protein

  4. NM_001169656.2 → NP_001163127.1  cuticular protein 49Ac, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH44

  5. NM_136928.5 → NP_610772.3  cuticular protein 49Ac, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610772.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960H8, Q9I7F5
    Related
    FBpp0087028
    Conserved Domains (1) summary
    pfam00379
    Location:145 → 196
    Chitin_bind_4; Insect cuticle protein

  6. NM_001299415.1 → NP_001286344.1  cuticular protein 49Ac, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF74
    Conserved Domains (1) summary
    pfam00379
    Location:136 → 187
    Chitin_bind_4; Insect cuticle protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LF74 A0A0B4LF74
A0A0B4LG85 A0A0B4LG85
E1JH44 E1JH44
Q7JR69 Q7JR69
Q960H8 Q960H8

Gene LinkOut

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