Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wfikkn1provided by RGD
Official Full Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1provided by RGD
Primary source: RGD:1565835
See related: AllianceGenome:RGD:1565835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oc29; RGD1565835
Summary: Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within muscle cell development; roof of mouth development; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 47.8), Adrenal (RPKM 37.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15400953..15403280, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14896442..14898770, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15243429..15245757, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OC29 may have a role in the early development of the inner ear sensory organ, particularly in the formation of the cristae of the semicircular canals [OC29]
Title: OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

Names: WAP, FS, Ig, KU, and NTR-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001129776.1 → NP_001123248.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_001123248.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

P0C5J5

UniProtKB/TrEMBL

A0A8L2UMW2

Conserved Domains (7) summary

cd05765
Location:204 → 284

Ig_3; Subgroup of the immunoglobulin (Ig) superfamily

smart00131
Location:361 → 413

KU; BPTI/Kunitz family of serine protease inhibitors

cd00104
Location:124 → 159

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam07679
Location:196 → 284

I-set; Immunoglobulin I-set domain

pfam00095
Location:34 → 80

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

cl00101
Location:311 → 356

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

cl02512
Location:431 → 541

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...