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Nepl10 Neprilysin-like 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36366, updated on 4-Jan-2025

Summary

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Official Symbol
Nepl10provided by FlyBase
Official Full Name
Neprilysin-like 10provided by FlyBase
Primary source
FLYBASE:FBgn0033742
Locus tag
Dmel_CG8550
See related
AllianceGenome:FB:FBgn0033742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8550; Dmel\CG8550
Summary
Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nepl10 in Genome Data Viewer
Location:
49A7-49A7; 2-67 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12471915..12474021)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8359420..8361526)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lachesin Neighboring gene dim gamma-tubulin 5 Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 44 receptor 2 Neighboring gene uncharacterized protein Neighboring gene fused lobes Neighboring gene stanley-cup

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  2. Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis. Ayyar S, et al. Development, 2003 Jul. PMID 12756169
  3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  4. Microarray analysis and organization of circadian gene expression in Drosophila. McDonald MJ, et al. Cell, 2001 Nov 30. PMID 11733057
  5. Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. Short SM, et al. G3 (Bethesda), 2013 May 20. PMID 23550122, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neprilysin-like 10
Names
CG8550-PA
Nepl10-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12471915..12474021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136943.2 → NP_610787.1  Neprilysin-like 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z910, E0R947
    Related
    FBpp0087046
    Conserved Domains (1) summary
    cl14813
    Location:41 → 608
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z910 A1Z910

Gene LinkOut

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