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Mrm1 mitochondrial rRNA methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363661, updated on 4-Jan-2025

Summary

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Official Symbol
Mrm1provided by RGD
Official Full Name
mitochondrial rRNA methyltransferase 1provided by RGD
Primary source
RGD:1566232
See related
EnsemblRapid:ENSRNOG00000027901 AllianceGenome:RGD:1566232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566232
Summary
Predicted to enable rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA modification. Predicted to be active in mitochondrial matrix. Orthologous to human MRM1 (mitochondrial rRNA methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 51.9), Adrenal (RPKM 46.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrm1 in Genome Data Viewer
Location:
10q26
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70187842..70194785, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69690406..69697326, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72136241..72143075, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553190 Neighboring gene uncharacterized LOC134480634 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene dehydrogenase/reductase 11 Neighboring gene gametogenetin binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). Lee KW, et al. J Biol Chem, 2014 Sep 5. PMID 25074936, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (guanosine-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rRNA 2'-O-methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rRNA methyltransferase 1, mitochondrial
Names
mitochondrial rRNA methyltransferase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108832.2 → NP_001102302.1  rRNA methyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_001102302.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HHL7, D3ZK81
    Related
    ENSRNOP00000034375.3, ENSRNOT00000030885.5
    Conserved Domains (3) summary
    COG0566
    Location:38 → 301
    SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]
    pfam00588
    Location:146 → 299
    SpoU_methylase; SpoU rRNA Methylase family
    pfam08032
    Location:50 → 125
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70187842..70194785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086490.2 → XP_038942418.1  rRNA methyltransferase 1, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd18105
    Location:68 → 225
    SpoU-like_MRM1; SAM-dependent rRNA methylase related to MRM1

  2. XM_039086493.2 → XP_038942421.1  rRNA methyltransferase 1, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl38912
    Location:21 → 142
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  3. XM_039086491.2 → XP_038942419.1  rRNA methyltransferase 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    TIGR00186
    Location:47 → 213
    rRNA_methyl_3; rRNA methylase, putative, group 3
    cl38912
    Location:144 → 214
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  4. XM_039086492.2 → XP_038942420.1  rRNA methyltransferase 1, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6HHL8
    Conserved Domains (2) summary
    TIGR00186
    Location:47 → 209
    rRNA_methyl_3; rRNA methylase, putative, group 3
    cl38912
    Location:144 → 210
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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