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Stac2 SH3 and cysteine rich domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363674, updated on 4-Jan-2025

Summary

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Official Symbol
Stac2provided by RGD
Official Full Name
SH3 and cysteine rich domain 2provided by RGD
Primary source
RGD:1305548
See related
EnsemblRapid:ENSRNOG00000004805 AllianceGenome:RGD:1305548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to be located in cytoplasmic side of plasma membrane. Orthologous to human STAC2 (SH3 and cysteine rich domain 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 22.3), Lung (RPKM 9.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stac2 in Genome Data Viewer
Location:
10q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83528741..83544583, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83032418..83048260, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85988367..86004209, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene ARF like GTPase 5C Neighboring gene calcium voltage-gated channel auxiliary subunit beta 1 Neighboring gene ribosomal protein L19 Neighboring gene uncharacterized LOC102548674 Neighboring gene F-box and leucine-rich repeat protein 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stac Proteins Suppress Ca(2+)-Dependent Inactivation of Neuronal l-type Ca(2+) Channels. Polster A, et al. J Neurosci, 2018 Oct 24. PMID 30201773, Free PMC Article
  2. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There is a large postnatal increase in Stac2 expression in forebrain and cerebellum.
    Title: Stac Proteins Suppress Ca(2+)-Dependent Inactivation of Neuronal l-type Ca(2+) Channels.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 and cysteine-rich domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399483.1 → NP_001386412.1  SH3 and cysteine-rich domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JU98, D0IN10
    Related
    ENSRNOP00000069019.3, ENSRNOT00000091978.3
    Conserved Domains (4) summary
    cd11985
    Location:293 → 345
    SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
    pfam16664
    Location:167 → 292
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cd20881
    Location:106 → 164
    C1_Stac2; protein kinase C conserved region 1 (C1 domain) found in SH3 and cysteine-rich domain-containing protein 2 (Stac2) and similar proteins
    cl17036
    Location:352 → 403
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83528741..83544583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269538.1 → XP_063125608.1  SH3 and cysteine-rich domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU98
    Related
    ENSRNOP00000108852.1, ENSRNOT00000136635.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108834.1: Suppressed sequence

    Description
    NM_001108834.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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