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Cyp301a1 Cytochrome P450 301a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36378, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp301a1provided by FlyBase
Official Full Name
Cytochrome P450 301a1provided by FlyBase
Primary source
FLYBASE:FBgn0033753
Locus tag
Dmel_CG8587
See related
AllianceGenome:FB:FBgn0033753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
301a1; CG8587; cutl; Cyp301A1; Dmel\CG8587
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in tergite morphogenesis. Is expressed in several structures, including adult integumentary system; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp301a1 in Genome Data Viewer
Location:
49B4-49B5; 2-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12566185..12569061)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8453690..8456566)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene frazzled Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Chloride channel-b Neighboring gene Sin3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cytochrome p450 conserved in insects is involved in cuticle formation. Sztal T, et al. PLoS One, 2012. PMID 22574182, Free PMC Article
  2. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. Najarro MA, et al. PLoS Genet, 2015 Nov. PMID 26619284, Free PMC Article
  3. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Brandt A, et al. Insect Mol Biol, 2002 Aug. PMID 12144699
  4. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
  5. dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Adler PN, et al. Dev Biol, 2013 Jul 1. PMID 23623898, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyp301a1 affects the formation of the adult cuticle in Drosophila melanogaster
    Title: A cytochrome p450 conserved in insects is involved in cuticle formation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tergite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 301a1
Names
CG8587-PA
Cyp301a1-PA
cytochrome P450
NP_610796.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12566185..12569061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136952.3 → NP_610796.1  cytochrome P450 301a1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6D6
    Related
    FBpp0086937
    Conserved Domains (1) summary
    cl12078
    Location:76 → 530
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V6D6.1 Q9V6D6

Gene LinkOut

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