U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Amph Amphiphysin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36383, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Amphprovided by FlyBase
Official Full Name
Amphiphysinprovided by FlyBase
Primary source
FLYBASE:FBgn0027356
Locus tag
Dmel_CG8604
See related
AllianceGenome:FB:FBgn0027356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Amp; amph; Bin1; CG8604; dAmp; Damp; DAMP; damph; dAmph; Dmel\CG8604
Summary
Predicted to enable phospholipid binding activity. Involved in protein localization; regulation of muscle contraction; and rhabdomere membrane biogenesis. Located in cleavage furrow and synapse. Is expressed in several structures, including epithelial cell; epithelium; garland cell; gut section; and larval somatic muscle cell. Used to study centronuclear myopathy 2. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to several human genes including BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Amph in Genome Data Viewer
Location:
49B7-49B8; 2-67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12593604..12612068)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8481109..8499573)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-b Neighboring gene Sin3A Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene long non-coding RNA:CR43909 Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit q Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Peter BJ, et al. Science, 2004 Jan 23. PMID 14645856
  2. Membrane-bending mechanism of amphiphysin N-BAR domains. Arkhipov A, et al. Biophys J, 2009 Nov 18. PMID 19917226, Free PMC Article
  3. Four-scale description of membrane sculpting by BAR domains. Arkhipov A, et al. Biophys J, 2008 Sep 15. PMID 18515394, Free PMC Article
  4. Osmotically-induced tension and the binding of N-BAR protein to lipid vesicles. Hutchison JB, et al. Soft Matter, 2016 Feb 28. PMID 26822233
  5. Membrane curvature: how BAR domains bend bilayers. Zimmerberg J, et al. Curr Biol, 2004 Mar 23. PMID 15043839

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
    Title: Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum.
  2. Our study indicates that the H0 helix and the BAR tip are necessary for efficient and organized self-assembly of amphiphysin/N-BAR
    Title: Structural insights into the cooperative remodeling of membranes by amphiphysin/BIN1.
  3. Cleavage furrow tips tubule formation requires the BAR domain of amphiphysin.
    Title: The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos.
  4. This study challenges the notion that synaptic Amphiphysin is involved exclusively in endocytosis and suggests a novel role for this protein in postsynaptic exocytosis
    Title: Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling.
  5. the structure of the Drosophila amphiphysin BAR domain was solved; the universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module
    Title: BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in exocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in synaptic vesicle endocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
amphiphysin
Names
Amph-PA
Amph-PB
Amph-PC
CG8604-PA
CG8604-PB
CG8604-PC
amphiphysin/BIN1
dAmphiphysin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12593604..12612068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078993.3 → NP_523717.1  amphiphysin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KLE5
    Related
    FBpp0086941
    Conserved Domains (2) summary
    cd07588
    Location:26 → 238
    BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
    cd11790
    Location:539 → 602
    SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains

  2. NM_001273990.1 → NP_001260919.1  amphiphysin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEW6
    Conserved Domains (2) summary
    cd07588
    Location:26 → 238
    BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
    cd11790
    Location:439 → 502
    SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains

  3. NM_001273991.1 → NP_001260920.1  amphiphysin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260920.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFR7
    Conserved Domains (2) summary
    cd07588
    Location:26 → 238
    BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
    cd11790
    Location:303 → 373
    SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEW6 A0A0B4KEW6
A0A0B4KFR7 A0A0B4KFR7
Q7KLE5 Q7KLE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous