Myl2 myosin light chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myl2provided by RGD
Official Full Name: myosin light chain 2provided by RGD
Primary source: RGD:1564245
See related: EnsemblRapid:ENSRNOG00000030848 AllianceGenome:RGD:1564245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mlc2; Mlc-2; MLC-2s/v
Summary: Predicted to enable actin monomer binding activity and calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction; cell growth involved in cardiac muscle cell development; and regulation of the force of heart contraction. Located in myofibril. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 31563.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40114964..40126236, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34454223..34468554, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (39951863..39959065, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
Title: Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
The MYL2 gene may be involved in the proliferation of spermatogonial stem cells and the process of sperm cells developing into mature sperm.
Title: [Expression of the MYL2 gene in the development of rat testis tissue].
Silencing MLCII by RNA interference reduced ALP activity (P<0.01), and eliminated RUNX2 mRNA expression (P<0.01). Addition of the MLC kinase inhibitor, ML7, reduced the CUCSassociated upregulation of RUNX2 expression (P<0.01) and ALP activity (P<0.01).
Title: Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
nuclear MYL2 plays an important role in IR injury by transcriptionally upregulating NOX2 expression to enhance oxidative stress in a phosphorylation-dependent manner.
Title: Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction.
We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease
Title: Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Prostanoid F receptor (FPR) signalling mechanism(s) regulating myosin light chain-2 phosphorylation likely extend beyond those classically established for G(q/11)-coupled receptors.
Title: Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE110694 (e-PCR)
- UniSTS:245286

Mylpc (e-PCR), detects polymorphism
- UniSTS:143968

Myl2 (e-PCR), detects polymorphism
- UniSTS:502683

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cardiac myofibril	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Names: cardiac myosin light chain-2; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035252.2 → NP_001030329.2 myosin regulatory light chain 2, ventricular/cardiac muscle isoform

See identical proteins and their annotated locations for NP_001030329.2

Status: PROVISIONAL

Source sequence(s)

BC126064

UniProtKB/Swiss-Prot

A0JMZ7, P08733

UniProtKB/TrEMBL

A0A8I5Y0S1

Related

ENSRNOP00000076784.1, ENSRNOT00000095667.2

Conserved Domains (1) summary

COG5126
Location:14 → 163

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

40114964..40126236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089640.2 → XP_038945568.1 myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1

UniProtKB/TrEMBL

A0A8I5Y0S1

Related

ENSRNOP00000039707.7, ENSRNOT00000050368.7

Conserved Domains (1) summary

COG5126
Location:1 → 144

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]