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Dgkepsilon Diacyl glycerol kinase epsilon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36408, updated on 4-Jan-2025

Summary

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Official Symbol
Dgkepsilonprovided by FlyBase
Official Full Name
Diacyl glycerol kinase epsilonprovided by FlyBase
Primary source
FLYBASE:FBgn0020930
Locus tag
Dmel_CG8657
See related
AllianceGenome:FB:FBgn0020930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8657; DGKe; dgkepsilon; DGKepsilon; Dmel\CG8657
Summary
Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process and intracellular signal transduction. Predicted to be active in membrane. Is expressed in several structures, including adult head; germ layer; germline cell; imaginal disc; and midgut primordium. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Dgkepsilon in Genome Data Viewer
Location:
49C2-49C2; 2-67 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12757546..12759724)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8645051..8647229)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tafazzin Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene oxen Neighboring gene Nascent polypeptide associated complex protein alpha subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKepsilon. Frolov MV, et al. Biochim Biophys Acta, 2001 Apr 23. PMID 11336805
  2. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. Zhang N, et al. J Biol Chem, 2012 Jun 15. PMID 22511757, Free PMC Article
  3. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
  4. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
  5. A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer. La Marca JE, et al. Dis Model Mech, 2023 Mar 1. PMID 36861754, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diacyl glycerol kinase epsilon
Names
CG8657-PA
CG8657-PB
Dgkepsilon-PA
Dgkepsilon-PB
diacylglycerol kinase epsilon
NP_001286362.1
NP_725228.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12757546..12759724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165949.2 → NP_725228.1  diacyl glycerol kinase epsilon, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YD90, O44334, Q7K579
    Related
    FBpp0086966
    Conserved Domains (4) summary
    smart00046
    Location:207 → 331
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:207 → 519
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00130
    Location:108 → 165
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00609
    Location:355 → 510
    DAGK_acc; Diacylglycerol kinase accessory domain

  2. NM_001299433.1 → NP_001286362.1  diacyl glycerol kinase epsilon, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286362.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YD90, O44334, Q7K579
    Conserved Domains (4) summary
    smart00046
    Location:207 → 331
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:207 → 519
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00130
    Location:108 → 165
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00609
    Location:355 → 510
    DAGK_acc; Diacylglycerol kinase accessory domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44334 O44334
Q7K579 Q7K579

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