U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sans Scaffold protein containing ankyrin repeats and SAM domain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36427, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Sansprovided by FlyBase
Official Full Name
Scaffold protein containing ankyrin repeats and SAM domainprovided by FlyBase
Primary source
FLYBASE:FBgn0033785
Locus tag
Dmel_CG13320
See related
AllianceGenome:FB:FBgn0033785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13320; Dmel\CG13320; DSANS; sans
Summary
Enables myosin binding activity. Involved in sensory perception of sound. Located in early endosome. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in Usher syndrome type 1G. Orthologous to human USH1G (USH1 protein network component sans) and ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sans in Genome Data Viewer
Location:
49E1-49E1; 2-67 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12936891..12940412)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8824396..8827917)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Squamous cell carcinoma-related oncogene 3 Neighboring gene uncharacterized protein Neighboring gene Multi drug resistance 49 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis. Sallee JL, et al. Dev Biol, 2021 Feb. PMID 33248112, Free PMC Article
  2. Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans. Demontis F, et al. PLoS One, 2009. PMID 19270738, Free PMC Article
  3. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. Li T, et al. Elife, 2016 Jun 22. PMID 27331610, Free PMC Article
  4. Using Drosophila to study mechanisms of hereditary hearing loss. Li T, et al. Dis Model Mech, 2018 May 31. PMID 29853544, Free PMC Article
  5. Fruit flies in biomedical research. Wangler MF, et al. Genetics, 2015 Mar. PMID 25624315, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
scaffold protein containing ankyrin repeats and SAM domain
Names
CG13320-PA
CG13320-PB
Sans-PA
Sans-PB
sans ortholog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12936891..12940412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136985.3 → NP_610829.1  scaffold protein containing ankyrin repeats and SAM domain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610829.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQL2
    Related
    FBpp0086903
    Conserved Domains (5) summary
    cd09517
    Location:443 → 508
    SAM_USH1G_HARP; SAM domain of USH1G_HARP family
    smart00454
    Location:447 → 503
    SAM; Sterile alpha motif
    cd00204
    Location:6 → 118
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:6 → 96
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:35 → 63
    ANK; ANK repeat [structural motif]

  2. NM_176160.2 → NP_788340.1  scaffold protein containing ankyrin repeats and SAM domain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQL2
    Related
    FBpp0086904
    Conserved Domains (5) summary
    cd09517
    Location:443 → 508
    SAM_USH1G_HARP; SAM domain of USH1G_HARP family
    smart00454
    Location:447 → 503
    SAM; Sterile alpha motif
    cd00204
    Location:6 → 118
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:6 → 96
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:35 → 63
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQL2 Q7JQL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools