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Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364298, updated on 27-Nov-2024

Summary

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Official Symbol
Pip4p1provided by RGD
Official Full Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1provided by RGD
Primary source
RGD:1307475
See related
EnsemblRapid:ENSRNOG00000009948 AllianceGenome:RGD:1307475
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem55b; RGD1307475
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in several processes, including phosphatidylinositol dephosphorylation; positive regulation of TORC1 signaling; and proton-transporting V-type ATPase complex assembly. Predicted to be active in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 97.8), Brain (RPKM 84.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pip4p1 in Genome Data Viewer
Location:
15p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26620399..26624369, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24146854..24150739, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27852152..27855999, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1 Neighboring gene purine nucleoside phosphorylase Neighboring gene ribosomal protein L23a, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Medina MW, et al. Arterioscler Thromb Vasc Biol, 2014 Sep. PMID 25035345, Free PMC Article
  2. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. Morioka S, et al. J Cell Sci, 2018 Mar 6. PMID 29378918
  3. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Ungewickell A, et al. Proc Natl Acad Sci U S A, 2005 Dec 27. PMID 16365287, Free PMC Article
  4. TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation. Hashimoto Y, et al. Genes Cells, 2018 Jun. PMID 29644770
  5. TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. Willett R, et al. Nat Commun, 2017 Nov 17. PMID 29146937, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton-transporting V-type ATPase complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton-transporting V-type ATPase complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to sterol depletion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sterol depletion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagocytic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
PtdIns-4,5-P(2) 4-phosphatase type I
ptdIns-4,5-P2 4-Ptase I
transmembrane protein 55B
transmembrane protein 55B-like
type 1 PtdIns-4,5-P2 4-Ptase
type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase
NP_001014255.1
XP_006251950.1
XP_006251951.1
XP_017455249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014233.2 → NP_001014255.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

    See identical proteins and their annotated locations for NP_001014255.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087604
    UniProtKB/Swiss-Prot
    Q5PPM8
    UniProtKB/TrEMBL
    A6KEC3
    Related
    ENSRNOP00000013225.5, ENSRNOT00000013225.8
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 277
    Tmemb_55A; Transmembrane protein 55A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26620399..26624369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251888.4 → XP_006251950.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    pfam09788
    Location:4 → 270
    Tmemb_55A; Transmembrane protein 55A

  2. XM_017599760.3 → XP_017455249.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X3

  3. XM_006251889.5 → XP_006251951.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLH6
    Related
    ENSRNOP00000096185.1, ENSRNOT00000115002.2
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 154
    Tmemb_55A; Transmembrane protein 55A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPM8.1 GenPept UniProtKB/Swiss-Prot:Q5PPM8

Gene LinkOut

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