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Rnf31 ring finger protein 31 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364386, updated on 4-Jan-2025

Summary

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Official Symbol
Rnf31provided by RGD
Official Full Name
ring finger protein 31provided by RGD
Primary source
RGD:1305513
See related
EnsemblRapid:ENSRNOG00000019438 AllianceGenome:RGD:1305513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of necroptotic process. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Predicted to be part of CD40 receptor complex and LUBAC complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 66.5), Spleen (RPKM 64.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf31 in Genome Data Viewer
Location:
15p13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33053450..33065285)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29083047..29095328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34270037..34282385)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome activator subunit 2 Neighboring gene interferon regulatory factor 9 Neighboring gene small ribosomal subunit protein uS19-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK). Bromann PA, et al. Gene Expr Patterns, 2004 Jan. PMID 14678832
  2. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Yamanaka K, et al. Nat Cell Biol, 2003 Apr. PMID 12629548
  3. Tumor necrosis factor. Chu WM. Cancer Lett, 2013 Jan 28. PMID 23085193, Free PMC Article
  4. Linear ubiquitination prevents inflammation and regulates immune signalling. Gerlach B, et al. Nature, 2011 Mar 31. PMID 21455173
  5. Molecular basis and regulation of OTULIN-LUBAC interaction. Elliott PR, et al. Mol Cell, 2014 May 8. PMID 24726323, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables linear polyubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of xenophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein linear polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein linear polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of LUBAC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF31
NP_001102338.2
XP_006252062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108868.1 → NP_001102338.2  E3 ubiquitin-protein ligase RNF31

    See identical proteins and their annotated locations for NP_001102338.2

    Status: PROVISIONAL

    Source sequence(s)
    CH474049
    UniProtKB/TrEMBL
    A0A8I6A2Y9, A6KH19, E9PU29
    Related
    ENSRNOP00000026333.5, ENSRNOT00000026333.9
    Conserved Domains (7) summary
    smart00647
    Location:769 → 831
    IBR; In Between Ring fingers
    cd14325
    Location:561 → 615
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:348 → 367
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:689 → 739
    NMD3; NMD3 family
    pfam16678
    Location:473 → 617
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
    cl00873
    Location:523 → 594
    PdxA; Pyridoxal phosphate biosynthetic protein PdxA
    cl15262
    Location:51 → 152
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33053450..33065285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252000.5 → XP_006252062.1  E3 ubiquitin-protein ligase RNF31 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2Y9
    Conserved Domains (8) summary
    smart00647
    Location:768 → 830
    IBR; In Between Ring fingers
    cd14325
    Location:560 → 614
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:348 → 367
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:688 → 738
    NMD3; NMD3 family
    pfam14636
    Location:365 → 516
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam16678
    Location:472 → 616
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
    cl00873
    Location:522 → 593
    PdxA; Pyridoxal phosphate biosynthetic protein PdxA
    cl15262
    Location:51 → 152
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
Nucleotide Protein Strain
Heading Accession and Version

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