U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ack-like Activated Cdc42 kinase-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36442, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Ack-likeprovided by FlyBase
Official Full Name
Activated Cdc42 kinase-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0263998
Locus tag
Dmel_CG43741
See related
AllianceGenome:FB:FBgn0263998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33007; CG3969; CG43741; dACK; Dmel\CG43741; DmHD-11; DPR2; DRODPR2; HD-11; PR2; PR2/ACK; Rp2
Old locus tag
Dmel_CG33007; Dmel_CG3969
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in dorsal closure, amnioserosa morphology change; head involution; and myosin filament assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior endoderm; dorsal epidermis primordium; embryonic dorsal epidermis; ganglia; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ack-like in Genome Data Viewer
Location:
49F3-49F4; 2-68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13142834..13152677, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9030339..9040182, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome associated protein G Neighboring gene Tripeptidyl-peptidase II Neighboring gene NADH dehydrogenase (ubiquinone) MWFE subunit Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog. Ito M, et al. Gene, 1994 Feb 25. PMID 8112607
  2. An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior. Dean KE, et al. PLoS One, 2013. PMID 24376789, Free PMC Article
  3. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. Burbelo PD, et al. J Biol Chem, 1995 Dec 8. PMID 7493928
  4. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Sem KP, et al. Mol Cell Biol, 2002 Jun. PMID 11997505, Free PMC Article
  5. Evolutionary expansion of CRIB-containing Cdc42 effector proteins. Pirone DM, et al. Trends Genet, 2001 Jul. PMID 11418196

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dorsal closure, amnioserosa morphology change IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in head involution IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myosin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
activated Cdc42 kinase-like
Names
Ack-like-PA
Ack-like-PC
Ack-like-PD
Ack-like-PE
CG43741-PA
CG43741-PC
CG43741-PD
CG43741-PE
Fak-like tyrosine kinase
tyrosine kinase
NP_001260934.1
NP_001260935.1
NP_477086.2
NP_477087.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13142834..13152677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057738.4 → NP_477086.2  activated Cdc42 kinase-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477086.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24316, Q960Z6, Q9I7F7, Q9V6K0
    Related
    FBpp0303361
    Conserved Domains (5) summary
    cd09539
    Location:4 → 65
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:133 → 396
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:400 → 454
    SH3; Src homology 3 domains
    cd00132
    Location:486 → 525
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd05040
    Location:137 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  2. NM_057739.4 → NP_477087.3  activated Cdc42 kinase-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477087.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9I7F7
    Conserved Domains (5) summary
    cd09539
    Location:4 → 65
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:133 → 396
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:400 → 454
    SH3; Src homology 3 domains
    cd00132
    Location:486 → 525
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd05040
    Location:137 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  3. NM_001274006.1 → NP_001260935.1  activated Cdc42 kinase-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFU0
    Conserved Domains (5) summary
    cd09539
    Location:4 → 65
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:133 → 396
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:400 → 454
    SH3; Src homology 3 domains
    cd00132
    Location:486 → 525
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd05040
    Location:137 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  4. NM_001274005.1 → NP_001260934.1  activated Cdc42 kinase-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260934.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEY9
    Conserved Domains (5) summary
    cd09539
    Location:4 → 65
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:133 → 396
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:400 → 454
    SH3; Src homology 3 domains
    cd00132
    Location:486 → 525
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd05040
    Location:137 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEY9 A0A0B4KEY9
A0A0B4KFU0 A0A0B4KFU0
Q9I7F7.3 Q9I7F7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools