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Shld2 shieldin complex subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364514, updated on 4-Jan-2025

Summary

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Official Symbol
Shld2provided by RGD
Official Full Name
shieldin complex subunit 2provided by RGD
Primary source
RGD:1565067
See related
EnsemblRapid:ENSRNOG00000059057 AllianceGenome:RGD:1565067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam35a; RGD1310009
Summary
Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in actin cytoskeleton; chromosome; and nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 169.3), Kidney (RPKM 79.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Shld2 in Genome Data Viewer
Location:
16p15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9554921..9646186, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9544940..9640323, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10570307..10661528, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene synaptotagmin 15 Neighboring gene ZW10 interacting kinetochore protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene glutamate dehydrogenase 1 Neighboring gene family with sequence similarity 25, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells. Tomida J, et al. EMBO J, 2018 Jun 15. PMID 29789392, Free PMC Article
  2. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Gupta R, et al. Cell, 2018 May 3. PMID 29656893, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
shieldin complex subunit 2
Names
family with sequence similarity 35, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025028.2 → NP_001020199.2  shieldin complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    BC089872, BF420607, CB613349, CR474249, FM098539
    UniProtKB/TrEMBL
    A6KFS6
    Conserved Domains (1) summary
    pfam15793
    Location:714 → 886
    FAM35_C; Protein family FAM35, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    9554921..9646186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771136.4 → XP_008769358.2  shieldin complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6KFS6, D3ZH67
    Related
    ENSRNOP00000073233.2, ENSRNOT00000085012.3
    Conserved Domains (1) summary
    pfam15793
    Location:715 → 886
    FAM35_C; Protein family FAM35, C-terminal

  2. XM_063275584.1 → XP_063131654.1  shieldin complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6KFS6, D3ZH67

  3. XM_017600194.3 → XP_017455683.1  shieldin complex subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam15793
    Location:229 → 400
    FAM35_C; Protein family FAM35, C-terminal

  4. XM_008771135.4 → XP_008769357.2  shieldin complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6KFS6, D3ZH67
    Conserved Domains (1) summary
    pfam15793
    Location:715 → 886
    FAM35_C; Protein family FAM35, C-terminal

  5. XM_017600195.3 → XP_017455684.1  shieldin complex subunit 2 isoform X5

    Conserved Domains (1) summary
    pfam15793
    Location:229 → 400
    FAM35_C; Protein family FAM35, C-terminal

  6. XM_063275586.1 → XP_063131656.1  shieldin complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A6KFS6
    Related
    ENSRNOP00000069549.3, ENSRNOT00000087737.3

  7. XM_039094703.2 → XP_038950631.1  shieldin complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6KFS6, D3ZH67
    Conserved Domains (1) summary
    pfam15793
    Location:715 → 886
    FAM35_C; Protein family FAM35, C-terminal

  8. XM_063275587.1 → XP_063131657.1  shieldin complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    A6KFS6

  9. XM_008771137.4 → XP_008769359.2  shieldin complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A6KFS6, D3ZH67
    Conserved Domains (1) summary
    pfam15793
    Location:715 → 886
    FAM35_C; Protein family FAM35, C-terminal

  10. XM_063275588.1 → XP_063131658.1  shieldin complex subunit 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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