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CG42319 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36473, updated on 4-Jan-2025

Summary

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Official Symbol
CG42319provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259219
Locus tag
Dmel_CG42319
See related
AllianceGenome:FB:FBgn0259219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17041; CG17042; Dmel\CG42319
Old locus tag
Dmel_CG17041; Dmel_CG17042
Summary
Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in dorsal head epidermis; dorsal pharyngeal muscle cell; embryonic brain; larval muscle system; and larval somatic muscle cell. Orthologous to human PDLIM2 (PDZ and LIM domain 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG42319 in Genome Data Viewer
Location:
49F13-49F15; 2-68 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13260101..13266336)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9147606..9153841)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 31 Receptor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article
  2. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
  3. Comprehensive Identification and Alternative Splicing of Microexons in Drosophila. Pang TL, et al. Front Genet, 2021. PMID 33859668, Free PMC Article
  4. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42319-PA
CG42319-PB
CG42319-PC
CG42319-PD
CG42319-PE
CG42319-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13260101..13266336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144176.2 → NP_001137648.1  uncharacterized protein Dmel_CG42319, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZE5
    Conserved Domains (1) summary
    cd00992
    Location:45 → 119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001103831.3 → NP_001097301.1  uncharacterized protein Dmel_CG42319, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2RVI0
    Conserved Domains (1) summary
    cd00992
    Location:45 → 119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. NM_137017.3 → NP_610861.2  uncharacterized protein Dmel_CG42319, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610861.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9B6, Q058Z0

  4. NM_165977.3 → NP_725274.1  uncharacterized protein Dmel_CG42319, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725274.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K076
    Related
    FBpp0289015

  5. NM_137016.4 → NP_610860.2  uncharacterized protein Dmel_CG42319, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610860.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K076
    Related
    FBpp0289014

  6. NM_165978.2 → NP_725275.1  uncharacterized protein Dmel_CG42319, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725275.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K076
    Related
    FBpp0289016
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RVI0 A2RVI0
B7YZE5 B7YZE5
Q058Z0 Q058Z0
Q7K076 Q7K076

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