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AttC Attacin-C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36484, updated on 4-Jan-2025

Summary

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Official Symbol
AttCprovided by FlyBase
Official Full Name
Attacin-Cprovided by FlyBase
Primary source
FLYBASE:FBgn0041579
Locus tag
Dmel_CG4740
See related
AllianceGenome:FB:FBgn0041579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
att; Att; att C; attacin; attacin c; Attacin C; attC; C; CG4740; DIM 16; DIM-16; Dmel\CG4740; MPAC
Summary
Involved in antibacterial humoral response and defense response to Gram-positive bacterium. Located in extracellular space. Is expressed in embryonic/larval hemolymph. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AttC in Genome Data Viewer
Location:
50A3-50A3; 2-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13393705..13394667)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9281210..9282172)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Baramicin A2 Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System. Candib A, et al. Cannabis Cannabinoid Res, 2024 Jun. PMID 37158809,
  2. Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Barekat A, et al. Sci Rep, 2016 May 4. PMID 27143646, Free PMC Article
  3. Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response. Kim J, et al. Mol Cells, 2006 Oct 31. PMID 17085976
  4. Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging. Wang M, et al. Aging (Albany NY), 2020 Jan 6. PMID 31907335, Free PMC Article
  5. Primary structure and in vitro antibacterial properties of the Drosophila melanogaster attacin C Pro-domain. Rabel D, et al. J Biol Chem, 2004 Apr 9. PMID 14744858

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data demonstrate an alphavirus antiviral response involving the Imd and Jak-STAT mediated expression of dptB and attC.
    Title: An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication.
  2. Study shows that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form.
    Title: Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in humoral immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to bacterium HEP PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Attacin-C
Names
AttC-PB
Attacin-C precursor
CG4740-PB
attacin
attacin C
attacinC
attackin
drosophila immune induced molecule 16
NP_523729.3
  • deletion mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13393705..13394667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079005.4 → NP_523729.3  Attacin-C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523729.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8ML72, Q95NH6, Q95NK2, Q95UA2, Q95UA3, Q95UA4, Q95UA5, Q9GPI3, Q9GPI4
    Conserved Domains (2) summary
    pfam03768
    Location:51 → 120
    Attacin_N; Attacin, N-terminal region
    pfam03769
    Location:122 → 240
    Attacin_C; Attacin, C-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95NH6.1 Q95NH6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials