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Rpn13 Regulatory particle non-ATPase 13 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36545, updated on 9-Dec-2024

Summary

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Official Symbol
Rpn13provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 13provided by FlyBase
Primary source
FLYBASE:FBgn0033886
Locus tag
Dmel_CG13349
See related
AllianceGenome:FB:FBgn0033886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13349; Dmel\CG13349; GC13349; p42E; rpn13
Summary
Predicted to enable endopeptidase activator activity; proteasome binding activity; and ubiquitin binding activity. Involved in positive regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rpn13 in Genome Data Viewer
Location:
50C17-50C18; 2-68 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13958545..13960404, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9846050..9847909, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DJ-1alpha Neighboring gene Argonaute-1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene Cathepsin L1 Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. Nath SR, et al. J Clin Invest, 2018 Aug 1. PMID 29809168, Free PMC Article
  2. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster. Nguyen NN, et al. Sci Rep, 2019 Feb 28. PMID 30816680, Free PMC Article
  3. Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster. Lipinszki Z, et al. J Cell Sci, 2009 Sep 1. PMID 19654212
  4. The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. Zhou Z, et al. J Mol Cell Biol, 2018 Jun 1. PMID 28992318
  5. Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila. Blount JR, et al. Sci Rep, 2018 May 31. PMID 29855490, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
regulatory particle non-ATPase 13
Names
CG13349-PA
CG13349-PB
CG13349-PD
CG13349-PE
CG13349-PF
CG13349-PG
Rpn13-PA
Rpn13-PB
Rpn13-PD
Rpn13-PE
Rpn13-PF
Rpn13-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13958545..13960404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137073.3 → NP_610917.1  regulatory particle non-ATPase 13, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610917.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZG7, B7YZG8, Q7K2G1, Q86NT4
    Related
    FBpp0086736
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:235 → 341
    RPN13_C; UCH-binding domain

  2. NM_001144190.2 → NP_001137662.1  regulatory particle non-ATPase 13, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFA6
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:267 → 376
    RPN13_C; UCH-binding domain

  3. NM_166025.2 → NP_725346.1  regulatory particle non-ATPase 13, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZG7, B7YZG8, Q7K2G1, Q86NT4
    Related
    FBpp0086737
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:235 → 341
    RPN13_C; UCH-binding domain

  4. NM_001144191.2 → NP_001137663.1  regulatory particle non-ATPase 13, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFA6
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:267 → 376
    RPN13_C; UCH-binding domain

  5. NM_001144192.2 → NP_001137664.1  regulatory particle non-ATPase 13, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137664.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZG7, B7YZG8, Q7K2G1, Q86NT4
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:235 → 341
    RPN13_C; UCH-binding domain

  6. NM_001299468.1 → NP_001286397.1  regulatory particle non-ATPase 13, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286397.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFA6
    Conserved Domains (2) summary
    cd13314
    Location:18 → 122
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:267 → 376
    RPN13_C; UCH-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFA6 A0A0B4LFA6
Q7K2G1.1 Q7K2G1

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