PheRS-m Phenylalanyl-tRNA synthetase, mitochondrial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PheRS-mprovided by FlyBase
Official Full Name: Phenylalanyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source: FLYBASE:FBgn0275436
Locus tag: Dmel_CG13348
See related: AllianceGenome:FB:FBgn0275436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aats-phe; Aats-phe-m; CG13348; dFARS; dFARS2; Dmel\CG13348; FRS; mtPheRS; PheRS; Pts
Summary: Enables phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Predicted to be active in mitochondrion. Is expressed in dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; somatic muscle primordium; and trunk visceral muscle primordium. Used to study developmental and epileptic encephalopathy and hereditary spastic paraplegia 77. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13968308..13969902)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9855813..9857407)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Hedgehog pathway is negatively regulated during the development of Drosophila melanogaster PheRS-m (Drosophila homologs gene of human FARS2) mutants.
Title: Hedgehog pathway is negatively regulated during the development of Drosophila melanogaster PheRS-m (Drosophila homologs gene of human FARS2) mutants.
A translation-independent function of PheRS activates growth and proliferation in Drosophila.
Title: A translation-independent function of PheRS activates growth and proliferation in Drosophila.
FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism.
Title: FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phenylalanine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phenylalanine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed
involved_in tRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

Names: CG13348-PA; PheRS-m-PA; Phenylalanyl-tRNA synthetase; mitochondrial phenylalanyl-tRNA synthetase

NP_477283.1

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