Paip1 poly(A) binding protein interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Paip1provided by RGD
Official Full Name: poly(A) binding protein interacting protein 1provided by RGD
Primary source: RGD:1305668
See related: EnsemblRapid:ENSRNOG00000058580 AllianceGenome:RGD:1305668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable translation activator activity. Predicted to be involved in post-transcriptional regulation of gene expression. Predicted to act upstream of with a positive effect on viral translation. Predicted to be located in cytosol. Predicted to be part of mCRD-mediated mRNA stability complex. Predicted to be active in cytoplasm. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 243.2), Kidney (RPKM 213.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (53255916..53282965)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (51523190..51550241)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (52300921..52328212)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect viral translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mCRD-mediated mRNA stability complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyadenylate-binding protein-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108937.2 → NP_001102407.1 polyadenylate-binding protein-interacting protein 1 isoform b

See identical proteins and their annotated locations for NP_001102407.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I5V5, B2RZ22

Related

ENSRNOP00000069142.3, ENSRNOT00000081157.3

Conserved Domains (1) summary

pfam02854
Location:48 → 264

MIF4G; MIF4G domain
NM_001399758.1 → NP_001386687.1 polyadenylate-binding protein-interacting protein 1 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

B2RZ22
NM_001399759.1 → NP_001386688.1 polyadenylate-binding protein-interacting protein 1 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I5V5, B2RZ22

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

53255916..53282965

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760778.4 → XP_008759000.1 polyadenylate-binding protein-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JVP5

Related

ENSRNOP00000069568.2, ENSRNOT00000091387.3

Conserved Domains (2) summary

PHA03160
Location:36 → 116

PHA03160; hypothetical protein; Provisional

pfam02854
Location:161 → 377

MIF4G; MIF4G domain