U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trim59 tripartite motif-containing 59 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365813, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Trim59provided by RGD
Official Full Name
tripartite motif-containing 59provided by RGD
Primary source
RGD:1311956
See related
EnsemblRapid:ENSRNOG00000010515 AllianceGenome:RGD:1311956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311956
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; negative regulation of canonical NF-kappaB signal transduction; and negative regulation of viral entry into host cell. Predicted to be located in endoplasmic reticulum. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 342.1), Thymus (RPKM 203.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Trim59 in Genome Data Viewer
Location:
2q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (155579183..155593450, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (153269210..153281185, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (165629903..165641751, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene microRNA 15b Neighboring gene structural maintenance of chromosomes 4 Neighboring gene microRNA 16 Neighboring gene karyopherin subunit alpha 4 Neighboring gene small Cajal body-specific RNA 7 Neighboring gene guanine nucleotide exchange factor MSS4-like Neighboring gene TOX high mobility group box family member 3 like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification. Liu Y, et al. J Transl Med, 2023 Nov 17. PMID 37978515, Free PMC Article
  2. TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways. Kondo T, et al. Biochem Biophys Res Commun, 2012 Jun 8. PMID 22588174
  3. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
    Title: A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
NOT part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tripartite motif-containing protein 59
NP_001102415.1
XP_006232546.1
XP_006232547.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108945.1 → NP_001102415.1  tripartite motif-containing protein 59

    See identical proteins and their annotated locations for NP_001102415.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    B5DF13, F7EYS6
    Conserved Domains (2) summary
    cd16763
    Location:5 → 60
    RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
    cd19790
    Location:95 → 134
    Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    155579183..155593450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232484.5 → XP_006232546.1  tripartite motif-containing protein 59 isoform X1

    See identical proteins and their annotated locations for XP_006232546.1

    UniProtKB/TrEMBL
    B5DF13, F7EYS6
    Related
    ENSRNOP00000111836.1, ENSRNOT00000171616.1
    Conserved Domains (2) summary
    cd16763
    Location:5 → 60
    RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
    cd19790
    Location:95 → 134
    Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

  2. XM_006232485.5 → XP_006232547.1  tripartite motif-containing protein 59 isoform X1

    See identical proteins and their annotated locations for XP_006232547.1

    UniProtKB/TrEMBL
    B5DF13, F7EYS6
    Related
    ENSRNOP00000013987.3, ENSRNOT00000013987.5
    Conserved Domains (2) summary
    cd16763
    Location:5 → 60
    RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
    cd19790
    Location:95 → 134
    Bbox2_TRIM59_C-XI; B-box-type 2 zinc finger found in tripartite motif-containing protein 59 (TRIM59) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools