Shrm Shroom [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Shrmprovided by FlyBase
Official Full Name: Shroomprovided by FlyBase
Primary source: FLYBASE:FBgn0085408
Locus tag: Dmel_CG34379
See related: AllianceGenome:FB:FBgn0085408
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13942; CG13944; CG34379; CG8603; Dmel\CG34379; dmShroom; dShrm; shrm; Shrooom
Old locus tag: CG13942; CG8603; Dmel_CG13942; Dmel_CG8603
Summary: Enables actin filament binding activity; kinase binding activity; and protein homodimerization activity. Involved in several processes, including actin cytoskeleton organization; establishment of planar polarity; and protein localization to adherens junction. Located in adherens junction; apical plasma membrane; and cortical actin cytoskeleton. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; extraembryonic structure; gut section; and head epidermis primordium. Orthologous to several human genes including SHROOM2 (shroom family member 2) and SHROOM3 (shroom family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14308142..14351802)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10195647..10239307)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization involved in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info