U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tra2 transformer 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36619, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
tra2provided by FlyBase
Official Full Name
transformer 2provided by FlyBase
Primary source
FLYBASE:FBgn0003742
Locus tag
Dmel_CG10128
See related
AllianceGenome:FB:FBgn0003742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10128; Dmel\CG10128; TRA 2; tra-2; Tra-2; TRA-2; Tra2; TRA2
Summary
Enables identical protein binding activity and pre-mRNA binding activity. Involved in female sex determination; mRNA splicing, via spliceosome; and regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in several structures, including embryonic epipharynx; germline cell; gonad; and larval labral sensory complex. Orthologous to several human genes including TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tra2 in Genome Data Viewer
Location:
51B6-51B6; 2-72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14602004..14604337, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10489509..10491842, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tout-velu Neighboring gene Lamin C Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU5-44 Neighboring gene RNA polymerase I subunit A Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analysis of a null mutation in the Drosophila splicing regulator Tra2 suggests its function is restricted to sexual differentiation. Unni E, et al. Genesis, 2003 Oct. PMID 14595843
  2. Differential control of yolk protein gene expression in fat bodies and gonads by the sex-determining gene tra-2 of Drosophila. Bownes M, et al. EMBO J, 1990 Dec. PMID 1701141, Free PMC Article
  3. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. Chen ZX, et al. G3 (Bethesda), 2015 Apr 7. PMID 25850426, Free PMC Article
  4. The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage. Mikoluk C, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29203241, Free PMC Article
  5. Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster. Belote JM, et al. Proc Natl Acad Sci U S A, 1987 Nov. PMID 3120181, Free PMC Article

See all (285) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together, these results suggest a link between mRNA splicing, sex determination and lipid metabolism and may provide insight into the mechanisms underlying tissue-specific splicing and nutrient storage.
    Title: The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage.
  2. results indicate the Hfp/Puf68 protein is required for the negative regulation of splicing by Tra2
    Title: Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.
  3. Anastrepha Tra2 protein supplies tra-2 function in Drosophila
    Title: Effect of the transformer-2 gene of Anastrepha on the somatic sexual development of Drosophila.
  4. Tra2 represses M1 splicing by interacting with multiple sequences in the pre-mRNA and interfering with enhancer function
    Title: Direct repression of splicing by transformer-2.
  5. Rbp1 and Tra2 bind to the ISS independently through distinct sequences suggesting that functionally synergistic interactions of these SR factors can cause either splicing activation or repression.
    Title: The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.
  6. Here we show that that widely used tra2 mutant alleles have residual activity and are not suitable for evaluating its effect on viability.
    Title: Analysis of a null mutation in the Drosophila splicing regulator Tra2 suggests its function is restricted to sexual differentiation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables pre-mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in female sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female somatic sex determination TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in male somatic sex determination TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sex determination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spliceosomal complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transformer 2
Names
CG10128-PA
CG10128-PB
CG10128-PC
CG10128-PD
CG10128-PE
CG10128-PF
CG10128-PG
Transformer-2
tra2-PA
tra2-PB
tra2-PC
tra2-PD
tra2-PE
tra2-PF
tra2-PG
transformer2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14602004..14604337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057416.3 → NP_476764.1  transformer 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476764.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH1, P19018, Q0E977, Q9V734
    Related
    FBpp0088562
    Conserved Domains (2) summary
    COG0724
    Location:74 → 242
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:98 → 175
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. NM_057415.3 → NP_476763.1  transformer 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476763.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19018
    Related
    FBpp0088563
    Conserved Domains (1) summary
    cl17169
    Location:98 → 133
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_057417.3 → NP_476765.1  transformer 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476765.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19018
    Related
    FBpp0088564
    Conserved Domains (2) summary
    COG0724
    Location:36 → 204
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:60 → 137
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  4. NM_206113.2 → NP_995835.1  transformer 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995835.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH1, P19018, Q0E977, Q9V734
    Conserved Domains (2) summary
    COG0724
    Location:74 → 242
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:98 → 175
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  5. NM_206112.2 → NP_995834.1  transformer 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH1, P19018, Q0E977, Q9V734
    Conserved Domains (2) summary
    COG0724
    Location:74 → 242
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:98 → 175
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  6. NM_134280.1 → NP_599107.1  transformer 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19018
    Related
    FBpp0088560, FBtr0089615
    Conserved Domains (2) summary
    COG0724
    Location:36 → 204
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:60 → 137
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  7. NM_057418.2 → NP_476766.1  transformer 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19018
    Related
    FBpp0088561, FBtr0089616
    Conserved Domains (2) summary
    COG0724
    Location:3 → 157
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12363
    Location:13 → 90
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19018.1 P19018

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous