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Dro Drosocin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36635, updated on 4-Jan-2025

Summary

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Official Symbol
Droprovided by FlyBase
Official Full Name
Drosocinprovided by FlyBase
Primary source
FLYBASE:FBgn0010388
Locus tag
Dmel_CG10816
See related
AllianceGenome:FB:FBgn0010388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
143609_at; BcDNA:RH31634; Btn; CG10816; DIM 11; DIM 15; DIM 9; DIM-15; Dmel\CG10816; drc; Drc; dro; Dro1; Droc; DROC; dros; Dros; drosocin; Drs; IM15; IM7
Summary
Involved in defense response to other organism and positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria. Located in extracellular region. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Dro in Genome Data Viewer
Location:
51C1-51C1; 2-72 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14745961..14746714)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10633466..10634219)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jet fuel Neighboring gene Attacin-A Neighboring gene Attacin-B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substitution of the GalNAc-α-O-Thr¹¹ residue in drosocin with O-linked glyco-peptoid residue: effect on antibacterial activity and conformational change. Ahn M, et al. Bioorg Med Chem Lett, 2011 Oct 15. PMID 21890357
  2. Inhibition of translation termination by the antimicrobial peptide Drosocin. Mangano K, et al. Nat Chem Biol, 2023 Sep. PMID 36997647, Free PMC Article
  3. A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution. Bulet P, et al. J Biol Chem, 1993 Jul 15. PMID 8325867
  4. Enlarged scale chemical synthesis and range of activity of drosocin, an O-glycosylated antibacterial peptide of Drosophila. Bulet P, et al. Eur J Biochem, 1996 May 15. PMID 8665953
  5. Structural basis for translation inhibition by the glycosylated drosocin peptide. Koller TO, et al. Nat Chem Biol, 2023 Sep. PMID 36997646, Free PMC Article

See all (318) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of translation termination by the antimicrobial peptide Drosocin.
    Title: Inhibition of translation termination by the antimicrobial peptide Drosocin.
  2. Structural basis for translation inhibition by the glycosylated drosocin peptide.
    Title: Structural basis for translation inhibition by the glycosylated drosocin peptide.
  3. Naturally occurring glycosylated forms of proline rich antibacterial peptide, drosocin, manifest structure-dependent antimicrobial activities.
    Title: Comparing naturally occurring glycosylated forms of proline rich antibacterial peptide, Drosocin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in antibacterial humoral response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to insect IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium HEP PubMed 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
drosocin
Names
CG10816-PA
CG10816-PB
Dro-PA
Dro-PB
Immune-induced molecule 7
buletin
drosocin (D)
drosocin precursor
drosophila immune induced molecule 11
drosophila immune induced molecule 15
drosophila immune induced molecule 9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14745961..14746714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259395.2 → NP_001246324.1  drosocin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246324.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36193, Q53ZZ5, Q867T5, Q86BV9, Q9V749
    UniProtKB/TrEMBL
    A0A0B4K7Q5

  2. NM_079020.5 → NP_523744.1  drosocin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36193, Q53ZZ5, Q867T5, Q86BV9, Q9V749
    UniProtKB/TrEMBL
    A0A0B4K7Q5
    Related
    FBpp0086566
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7Q5 A0A0B4K7Q5
P36193.2 P36193

Gene LinkOut

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