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Rbm25 RNA binding motif protein 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366693, updated on 4-Jan-2025

Summary

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Official Symbol
Rbm25provided by RGD
Official Full Name
RNA binding motif protein 25provided by RGD
Primary source
RGD:1308755
See related
EnsemblRapid:ENSRNOG00000002874 AllianceGenome:RGD:1308755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to be located in nuclear speck. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 173.5), Spleen (RPKM 152.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm25 in Genome Data Viewer
Location:
6q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108993119..109050159)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103271775..103319090)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107117888..107165538)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479227 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene uncharacterized LOC134479226 Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene uncharacterized LOC102547293 Neighboring gene presenilin 1 Neighboring gene papilin, proteoglycan-like sulfated glycoprotein Neighboring gene NUMB, endocytic adaptor protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells. Tian X, et al. PeerJ, 2023. PMID 37953772, Free PMC Article
  2. RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress. Zhu Z, et al. Cell Stress Chaperones, 2023 Nov. PMID 37736860, Free PMC Article
  3. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Zhou A, et al. Mol Cell Biol, 2008 Oct. PMID 18663000, Free PMC Article
  4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
    Title: RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
  2. RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells.
    Title: RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395131.1 → NP_001382060.1  RNA-binding protein 25

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JDQ4, F1LT30
    Related
    ENSRNOP00000003834.8, ENSRNOT00000003834.9
    Conserved Domains (2) summary
    smart00311
    Location:756 → 829
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    108993119..109050159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262229.1 → XP_063118299.1  RNA-binding protein 25 isoform X6

  2. XM_063262223.1 → XP_063118293.1  RNA-binding protein 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMR5, F1LT30

  3. XM_063262225.1 → XP_063118295.1  RNA-binding protein 25 isoform X3

    UniProtKB/TrEMBL
    A6JDQ4, F1LT30

  4. XM_039112644.2 → XP_038968572.1  RNA-binding protein 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMR5, F1LT30
    Related
    ENSRNOP00000097947.1, ENSRNOT00000113578.2
    Conserved Domains (2) summary
    smart00311
    Location:775 → 848
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  5. XM_039112645.2 → XP_038968573.1  RNA-binding protein 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMR5, F1LT30
    Conserved Domains (2) summary
    smart00311
    Location:775 → 848
    PWI; domain in splicing factors
    cd12446
    Location:106 → 188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  6. XM_063262224.1 → XP_063118294.1  RNA-binding protein 25 isoform X2

    UniProtKB/TrEMBL
    F1LT30

  7. XM_039112647.2 → XP_038968575.1  RNA-binding protein 25 isoform X3

    UniProtKB/TrEMBL
    A6JDQ4, F1LT30
    Conserved Domains (2) summary
    smart00311
    Location:756 → 829
    PWI; domain in splicing factors
    cd12446
    Location:87 → 169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

  8. XM_063262226.1 → XP_063118296.1  RNA-binding protein 25 isoform X4

    UniProtKB/TrEMBL
    F1LT30

  9. XM_063262227.1 → XP_063118297.1  RNA-binding protein 25 isoform X5

  10. XM_063262228.1 → XP_063118298.1  RNA-binding protein 25 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108984.1: Suppressed sequence

    Description
    NM_001108984.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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