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ckn caskin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36673, updated on 9-Dec-2024

Summary

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Official Symbol
cknprovided by FlyBase
Official Full Name
caskinprovided by FlyBase
Primary source
FLYBASE:FBgn0033987
Locus tag
Dmel_CG12424
See related
AllianceGenome:FB:FBgn0033987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM06913; CG12424; Dmel\CG12424
Summary
Enables protein phosphatase binding activity and signaling adaptor activity. Involved in axon guidance and cell surface receptor protein tyrosine phosphatase signaling pathway. Located in axon; cytoplasm; and focal adhesion. Is expressed in several structures, including clypeo-labral anlage; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and larval imaginal tissue. Orthologous to human CASKIN1 (CASK interacting protein 1); CASKIN2 (CASK interacting protein 2); and OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ckn in Genome Data Viewer
Location:
51D6-51D6; 2-73 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14963292..14980795)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10850797..10868300)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lap1 Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C Neighboring gene transfer RNA:Leucine-AAG 1-1 Neighboring gene parcas Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. Weng YL, et al. J Neurosci, 2011 Mar 23. PMID 21430143, Free PMC Article
  2. dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. Yang Y, et al. PLoS Genet, 2021 Oct. PMID 34644293, Free PMC Article
  3. FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. Nechipurenko IV, et al. J Cell Biol, 2012 Feb 6. PMID 22312004, Free PMC Article
  4. Drosophila R8 photoreceptor cell subtype specification requires hibris. Tan H, et al. PLoS One, 2020. PMID 33052948, Free PMC Article
  5. A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. Kotian N, et al. G3 (Bethesda), 2022 Jan 4. PMID 34849760, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related
    Title: The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine phosphatase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine phosphatase signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caskin
Names
CG12424-PB
CG12424-PC
CG12424-PD
CG12424-PE
CG12424-PF
ckn-PB
ckn-PC
ckn-PD
ckn-PE
ckn-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14963292..14980795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137165.2 → NP_611009.1  caskin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611009.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQG5
    Related
    FBpp0311860
    Conserved Domains (4) summary
    cd09497
    Location:254 → 319
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:320 → 390
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:326 → 387
    SAM; Sterile alpha motif
    pfam16632
    Location:887 → 912
    Caskin-tail; C-terminal region of Caskin

  2. NM_166077.2 → NP_725434.1  caskin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQG5
    Related
    FBpp0086540
    Conserved Domains (4) summary
    cd09497
    Location:254 → 319
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:320 → 390
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:326 → 387
    SAM; Sterile alpha motif
    pfam16632
    Location:887 → 912
    Caskin-tail; C-terminal region of Caskin

  3. NM_001299508.1 → NP_001286437.1  caskin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286437.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFD7
    Conserved Domains (4) summary
    cd09497
    Location:254 → 319
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:320 → 390
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:326 → 387
    SAM; Sterile alpha motif
    pfam16632
    Location:808 → 833
    Caskin-tail; C-terminal region of Caskin

  4. NM_166076.2 → NP_725433.1  caskin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JQG5
    Related
    FBpp0086542
    Conserved Domains (4) summary
    cd09497
    Location:254 → 319
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:320 → 390
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:326 → 387
    SAM; Sterile alpha motif
    pfam16632
    Location:887 → 912
    Caskin-tail; C-terminal region of Caskin

  5. NM_001299509.1 → NP_001286438.1  caskin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF60
    Conserved Domains (3) summary
    cd09498
    Location:45 → 108
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:46 → 105
    SAM; Sterile alpha motif
    pfam16632
    Location:605 → 630
    Caskin-tail; C-terminal region of Caskin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LF60 A0A0B4LF60
A0A0B4LFD7 A0A0B4LFD7
Q7JQG5 Q7JQG5
Q8T948 Q8T948

Gene LinkOut

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