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CG11807 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36683, updated on 4-Jan-2025

Summary

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Official Symbol
CG11807provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033996
Locus tag
Dmel_CG11807
See related
AllianceGenome:FB:FBgn0033996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT14564; Dmel\CG11807
Summary
Predicted to enable integrin binding activity and phosphatidylinositol binding activity. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG11807 in Genome Data Viewer
Location:
51E5-51E5; 2-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15201253..15204466)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11088758..11091971)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Golgi pH Regulator Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 51a Neighboring gene relative of woc Neighboring gene Ionotropic receptor 51b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
  2. Differential evolutionary wiring of the tyrosine kinase Btk. Nawaz HM, et al. PLoS One, 2012. PMID 22574122, Free PMC Article
  3. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article
  4. Phosphoinositide signalling in Drosophila. Balakrishnan SS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25449646
  5. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11807-PA
CG11807-PB
CG11807-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15201253..15204466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274061.2 → NP_001260990.1  uncharacterized protein Dmel_CG11807, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K490
    Conserved Domains (4) summary
    cd06875
    Location:8 → 126
    PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
    sd00033
    Location:315 → 336
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:381 → 422
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:335 → 414
    LRR_8; Leucine rich repeat

  2. NM_001274062.2 → NP_001260991.1  uncharacterized protein Dmel_CG11807, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260991.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K490
    Conserved Domains (4) summary
    cd06875
    Location:8 → 126
    PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
    sd00033
    Location:315 → 336
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:381 → 422
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:335 → 414
    LRR_8; Leucine rich repeat

  3. NM_137173.5 → NP_611017.1  uncharacterized protein Dmel_CG11807, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K490
    Related
    FBpp0086496
    Conserved Domains (4) summary
    cd06875
    Location:8 → 126
    PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
    sd00033
    Location:315 → 336
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:381 → 422
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:335 → 414
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K490 Q7K490

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