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Hr51 Hormone receptor 51 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36702, updated on 9-Dec-2024

Summary

Official Symbol
Hr51provided by FlyBase
Official Full Name
Hormone receptor 51provided by FlyBase
Primary source
FLYBASE:FBgn0034012
Locus tag
Dmel_CG16801
See related
AllianceGenome:FB:FBgn0034012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16801; CG16801/NR2E3; DHR51; Dmel\CG16801; fdx; HR51; Nr2e3; NR2E3; PNR; unf; UNF
Summary
Enables chromatin binding activity and heme binding activity. Involved in several processes, including imaginal disc-derived wing expansion; locomotor rhythm; and nervous system development. Located in nucleus. Is expressed in several structures, including LNv neurons; embryonic/larval midgut; ganglia; gland; and nephrocyte. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Hr51 in Genome Data Viewer
Location:
51F7-51F7; 2-74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15331325..15339384)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11218830..11226889)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44371 Neighboring gene uncharacterized protein Neighboring gene unc-5 Neighboring gene long non-coding RNA:CR44458 Neighboring gene long non-coding RNA:CR44459 Neighboring gene Pms2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hormone receptor 51
Names
CG16801-PC
Hr51-PC
drosophila hormone receptor 51
failure to deploy or expand
hormone receptor at 51
unfulfilled

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15331325..15339384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137188.3NP_611032.2  hormone receptor 51 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611032.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA01
    Conserved Domains (2) summary
    cd06950
    Location:354569
    NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
    cd06970
    Location:103194
    NR_DBD_PNR; DNA-binding domain of the photoreceptor cell-specific nuclear receptor (PNR) is composed of two C4-type zinc fingers