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Ir52a Ionotropic receptor 52a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36715, updated on 4-Jan-2025

Summary

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Official Symbol
Ir52aprovided by FlyBase
Official Full Name
Ionotropic receptor 52aprovided by FlyBase
Primary source
FLYBASE:FBgn0034023
Locus tag
Dmel_CG12960
See related
AllianceGenome:FB:FBgn0034023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
52a; CG12960; DmelIR52a; Dmel\CG12960; IR52a
Summary
Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult gustatory receptor neurons; appendage; leg mechanosensory bristle; and spermatozoon. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ir52a in Genome Data Viewer
Location:
52A6-52A6; 2-74 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15499632..15501431)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11387137..11388936)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 52b Neighboring gene Ionotropic receptor 52c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex Mysteries of the Fly Courtship Master Regulator Fruitless. Sato K, et al. Front Behav Neurosci, 2019. PMID 31680899, Free PMC Article
  2. Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster. Dhakal S, et al. Commun Biol, 2021 Nov 12. PMID 34773080, Free PMC Article
  3. Calcium Taste Avoidance in Drosophila. Lee Y, et al. Neuron, 2018 Jan 3. PMID 29276056, Free PMC Article
  4. Mechanism of Acetic Acid Gustatory Repulsion in Drosophila. Rimal S, et al. Cell Rep, 2019 Feb 5. PMID 30726729, Free PMC Article
  5. Candidate ionotropic taste receptors in the Drosophila larva. Stewart S, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25825777, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Optogenetic activation of IR52a+ neurons in the wing activates second-order projections in the subesophageal zone.
    Title: Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated monoatomic ion channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
ionotropic receptor 52a
Names
CG12960-PB
Ir52a-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15499632..15501431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137197.2 → NP_611041.2  ionotropic receptor 52a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611041.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A077DCM6, A1ZA14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZA14 A1ZA14

Gene LinkOut

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