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Rab23 RAB23, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 367242, updated on 27-Nov-2024

Summary

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Official Symbol
Rab23provided by RGD
Official Full Name
RAB23, member RAS oncogene familyprovided by RGD
Primary source
RGD:1306867
See related
EnsemblRapid:ENSRNOG00000012629 AllianceGenome:RGD:1306867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity. Predicted to be involved in several processes, including cellular defense response; negative regulation of protein import into nucleus; and organelle assembly. Predicted to act upstream of or within several processes, including embryonic morphogenesis; regulation of smoothened signaling pathway; and spinal cord dorsal/ventral patterning. Predicted to be located in several cellular components, including centrosome; cytosol; and phagocytic vesicle. Predicted to be active in autophagosome and endosome membrane. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human RAB23 (RAB23, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 113.7), Brain (RPKM 52.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab23 in Genome Data Viewer
Location:
9q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43440047..43463327)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (35943522..35967367)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38469784..38496185, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene DNA primase subunit 2 Neighboring gene cofilin-2, pseudogene 2 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 5 Neighboring gene BAG cochaperone 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Jenkins D, et al. Am J Hum Genet, 2007 Jun. PMID 17503333, Free PMC Article
  2. Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization. Guo A, et al. J Neurosci Res, 2006 May 1. PMID 16463280
  3. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Nozawa T, et al. Cell Microbiol, 2012 Aug. PMID 22452336
  4. Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner. Chi S, et al. Cell Signal, 2012 Jun. PMID 22365972, Free PMC Article
  5. Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Günther T, et al. Development, 1994 Nov. PMID 7720556

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular defense response ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in craniofacial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-23
NP_001102475.1
XP_008765183.1
XP_017452053.1
XP_017452055.1
XP_017452056.1
XP_017452058.1
XP_038939895.1
XP_038939896.1
XP_038939897.1
XP_063123574.1
XP_063123575.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109005.2 → NP_001102475.1  ras-related protein Rab-23

    See identical proteins and their annotated locations for NP_001102475.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    43440047..43463327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596564.3 → XP_017452053.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  2. XM_017596569.3 → XP_017452058.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  3. XM_008766961.4 → XP_008765183.1  ras-related protein Rab-23 isoform X1

    See identical proteins and their annotated locations for XP_008765183.1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  4. XM_039083967.2 → XP_038939895.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  5. XM_039083968.2 → XP_038939896.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  6. XM_017596566.3 → XP_017452055.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Related
    ENSRNOP00000072716.1, ENSRNOT00000090385.3
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  7. XM_039083969.2 → XP_038939897.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  8. XM_017596567.3 → XP_017452056.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
    Conserved Domains (1) summary
    cd04106
    Location:10 → 169
    Rab23_like; Rab GTPase family 23 (Rab23)-like

  9. XM_063267504.1 → XP_063123574.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5

  10. XM_063267505.1 → XP_063123575.1  ras-related protein Rab-23 isoform X1

    UniProtKB/TrEMBL
    A6IN92, D3ZRM5
Nucleotide Protein Strain
Heading Accession and Version

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