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IgG-2a gamma-2a immunoglobulin heavy chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 367586, updated on 4-Jan-2025

Summary

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Symbol
IgG-2aprovided by RGD
Full Name
gamma-2a immunoglobulin heavy chainprovided by RGD
Primary source
RGD:1359626
See related
AllianceGenome:RGD:1359626
Gene type
protein coding
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Predicted to be part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
not in current annotation release
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Genomic context

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Location:
6q32

Bibliography

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Related articles in PubMed

  1. Evolution of the rat immunoglobulin gamma heavy-chain gene family. Brüggemann M. Gene, 1988 Dec 30. PMID 3149946
  2. Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes. Brüggemann M, et al. Proc Natl Acad Sci U S A, 1986 Aug. PMID 3016742, Free PMC Article
  3. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • Ig gamma-2a-chain
  • immunoglobulin gamma-2a chain

Clone Names

  • MGC109083, MGC109134

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Names
gamma-2a immunoglobulin heavy chain
Ig gamma-2a-chain
immunoglobulin gamma-2a chain

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014081.1: Suppressed sequence

    Description
    NM_001014081.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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