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SP2353 SP2353 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36771, updated on 9-Dec-2024

Summary

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Official Symbol
SP2353provided by FlyBase
Official Full Name
SP2353provided by FlyBase
Primary source
FLYBASE:FBgn0034070
Locus tag
Dmel_CG8403
See related
AllianceGenome:FB:FBgn0034070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH12319; CG8403; CT18665; Dmel\CG8403; Hspg2
Summary
Predicted to enable calcium ion binding activity. Involved in muscle cell cellular homeostasis and rhabdomere development. Predicted to be located in extracellular matrix. Orthologous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See SP2353 in Genome Data Viewer
Location:
52D15-52E1; 2-76 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16031930..16047243)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11919435..11934748)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene caspar Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-137 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina. Husain N, et al. Dev Cell, 2006 Oct. PMID 17011488
  2. An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila. Liu Z, et al. Mol Brain, 2020 Jan 3. PMID 31900209, Free PMC Article
  3. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. Marrone AK, et al. BMC Neurosci, 2011 Sep 26. PMID 21943192, Free PMC Article
  4. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Kucherenko MM, et al. Dev Biol, 2011 Apr 15. PMID 21256839
  5. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of innate immune response HMP PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SP2353
Names
CG8403-PA
CG8403-PB
SP2353-PA
SP2353-PB
agrin-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16031930..16047243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299545.1 → NP_001286474.1  SP2353, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286474.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA87, Q9NGV2
    Conserved Domains (4) summary
    smart00282
    Location:1205 → 1340
    LamG; Laminin G domain
    cd00110
    Location:625 → 774
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:583 → 612
    EGF; EGF-like domain
    pfam14670
    Location:53 → 82
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. NM_137238.4 → NP_611082.2  SP2353, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611082.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA87, Q9NGV2
    Related
    FBpp0086351
    Conserved Domains (4) summary
    smart00282
    Location:1205 → 1340
    LamG; Laminin G domain
    cd00110
    Location:625 → 774
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:583 → 612
    EGF; EGF-like domain
    pfam14670
    Location:53 → 82
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZA87 A1ZA87
Q8MRN8 Q8MRN8
Q9NGV2 Q9NGV2

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