Ric Ras-related protein interacting with calmodulin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ricprovided by FlyBase
Official Full Name: Ras-related protein interacting with calmodulinprovided by FlyBase
Primary source: FLYBASE:FBgn0265605
Locus tag: Dmel_CG8418
See related: AllianceGenome:FB:FBgn0265605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 17137290; CG8418; D-Ric; Dmel\CG8418; Q7JMZ0; RIC; Roc
Summary: Enables calmodulin binding activity. Involved in several processes, including response to heat; response to osmotic stress; and response to oxidative stress. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in organism and pole plasm. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to several human genes including RIT2 (Ras like without CAAX 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16107440..16110017, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11994945..11997522, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster.
Title: Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster.
Rich activates Rab6 to regulate N-Cadherin trafficking and affects synaptic specificity.
Title: Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
Activated RIC interacts with calmodulin during Drosophila development.
Title: Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG8418-PA; CG8418-PB; Ras operated by calmodulin; Ras which interacts with calmodulin; Ras-related which interacted with calmodulin; Ric-PA; Ric-PB

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The following sections contain reference sequences that belong to a specific genome build. Explain