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caly calypso [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36794, updated on 9-Dec-2024

Summary

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Official Symbol
calyprovided by FlyBase
Official Full Name
calypsoprovided by FlyBase
Primary source
FLYBASE:FBgn0262166
Locus tag
Dmel_CG8445
See related
AllianceGenome:FB:FBgn0262166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bap1; BAP1; Calypso; CG8445; Dmel\CG8445; Q7K5N4
Summary
Enables chromatin binding activity and cysteine-type deubiquitinase activity. Involved in heterochromatin formation and specification of segmental identity, abdomen. Located in chromatin and nucleus. Part of PR-DUB complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in basal cell carcinoma; extrahepatic bile duct adenocarcinoma; and uveal melanoma. Orthologous to human BAP1 (BRCA1 associated deubiquitinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See caly in Genome Data Viewer
Location:
52F7-52F7; 2-78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16194062..16196333, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12081567..12083838, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lissencephaly-1 Neighboring gene uncharacterized protein Neighboring gene clueless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. Foglizzo M, et al. Nat Commun, 2018 Sep 26. PMID 30258054, Free PMC Article
  2. Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX. De I, et al. Structure, 2019 Mar 5. PMID 30639226
  3. Molecular Regulation of the Polycomb Repressive-Deubiquitinase. Reddington CJ, et al. Int J Mol Sci, 2020 Oct 22. PMID 33105797, Free PMC Article
  4. PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction. Bonnet J, et al. Genes Dev, 2022 Oct 1. PMID 36357125, Free PMC Article
  5. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Li T, et al. Epigenetics Chromatin, 2017 Sep 19. PMID 28927461, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in specification of segmental identity, abdomen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PR-DUB complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PR-DUB complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calypso
Names
CG8445-PA
CG8445-PB
caly-PA
caly-PB
ubiquitin thiolesterase
NP_611096.1
NP_788374.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16194062..16196333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176194.2 → NP_788374.1  calypso, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K5N4
    Related
    FBpp0086384
    Conserved Domains (1) summary
    cd09617
    Location:46 → 274
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1

  2. NM_137252.3 → NP_611096.1  calypso, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611096.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K5N4
    Related
    FBpp0086383
    Conserved Domains (1) summary
    cd09617
    Location:46 → 274
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K5N4.1 Q7K5N4

Gene LinkOut

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