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Lipt1 Lipoyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36795, updated on 9-Dec-2024

Summary

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Official Symbol
Lipt1provided by FlyBase
Official Full Name
Lipoyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0265178
Locus tag
Dmel_CG44243
See related
AllianceGenome:FB:FBgn0265178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG44243; CG8446; Dmel\CG44243
Summary
Predicted to enable lipoyltransferase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic anal pad; gut section; larval muscle cell; larval muscle system; and posterior midgut primordium. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Lipt1 in Genome Data Viewer
Location:
52F7-52F8; 2-78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16197042..16199555)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12084547..12087060)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene clueless Neighboring gene calypso Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SH2 ankyrin repeat kinase Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene mrj Neighboring gene transfer RNA:Glutamic acid-TTC 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
  2. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
  3. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein lipoylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lipoyltransferase 1
Names
CG44243-PA
CG44243-PB
Lipt1-PA
Lipt1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16197042..16199555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202029.2 → NP_001188958.1  lipoyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX78, Q9V7K4
    Conserved Domains (2) summary
    TIGR00545
    Location:60 → 380
    lipoyltrans; lipoyltransferase and lipoate-protein ligase
    COG0095
    Location:63 → 311
    LplA; Lipoate-protein ligase A [Coenzyme transport and metabolism]

  2. NM_137253.5 → NP_611097.2  lipoyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611097.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX78, Q9V7K4
    Related
    FBpp0308232
    Conserved Domains (2) summary
    TIGR00545
    Location:60 → 380
    lipoyltrans; lipoyltransferase and lipoate-protein ligase
    COG0095
    Location:63 → 311
    LplA; Lipoate-protein ligase A [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX78 Q8SX78

Gene LinkOut

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