U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Baz1b bromodomain adjacent to zinc finger domain, 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 368002, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Baz1bprovided by RGD
Official Full Name
bromodomain adjacent to zinc finger domain, 1Bprovided by RGD
Primary source
RGD:1597089
See related
EnsemblRapid:ENSRNOG00000001453 AllianceGenome:RGD:1597089
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone H2AXY142 kinase activity and histone binding activity. Predicted to be involved in several processes, including negative regulation of mitotic chromosome condensation; positive regulation of transcription by RNA polymerase III; and post-translational protein modification. Predicted to act upstream of or within chromatin organization. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of B-WICH complex and WICH complex. Orthologous to human BAZ1B (bromodomain adjacent to zinc finger domain 1B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 247.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Baz1b in Genome Data Viewer
Location:
12q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27068541..27126511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21431985..21489956, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24478882..24536851, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481280 Neighboring gene frizzled class receptor 9 Neighboring gene 5S ribosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7B Neighboring gene transducin (beta)-like 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Poot RA, et al. Nat Cell Biol, 2004 Dec. PMID 15543136
  2. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Xiao A, et al. Nature, 2009 Jan 1. PMID 19092802, Free PMC Article
  3. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. Bozhenok L, et al. EMBO J, 2002 May 1. PMID 11980720, Free PMC Article
  4. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S, et al. Nat Rev Mol Cell Biol, 2013 Oct. PMID 24002223
  5. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC, et al. Cell Res, 2011 Mar. PMID 21358755, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
  
part_of WICH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WICH complex ISO
Inferred from Sequence Orthology
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase BAZ1B
Names
bromodomain adjacent to zinc finger domain protein 1B
NP_001178845.1
XP_038945581.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191916.1 → NP_001178845.1  tyrosine-protein kinase BAZ1B

    See identical proteins and their annotated locations for NP_001178845.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6ALC2, A6J0E2, G3V661
    Related
    ENSRNOP00000094596.1, ENSRNOT00000100108.2
    Conserved Domains (7) summary
    cd05505
    Location:1337 → 1433
    Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
    smart00571
    Location:602 → 666
    DDT; domain in different transcription and chromosome remodeling factors
    cd15628
    Location:1183 → 1228
    PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
    pfam10537
    Location:21 → 120
    WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
    pfam15612
    Location:722 → 771
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:897 → 925
    WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2
    pfam15614
    Location:988 → 1026
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    27068541..27126511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089653.2 → XP_038945581.1  tyrosine-protein kinase BAZ1B isoform X1

    UniProtKB/TrEMBL
    G3V661
    Conserved Domains (7) summary
    cd05505
    Location:1040 → 1136
    Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...
    smart00571
    Location:305 → 369
    DDT; domain in different transcription and chromosome remodeling factors
    cd15628
    Location:886 → 931
    PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)
    pfam17380
    Location:464 → 562
    DUF5401; Family of unknown function (DUF5401)
    pfam15612
    Location:428 → 468
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:599 → 725
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    pfam15709
    Location:210 → 270
    DUF4670; Domain of unknown function (DUF4670)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous