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Dgkd diacylglycerol kinase, delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 368088, updated on 27-Nov-2024

Summary

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Official Symbol
Dgkdprovided by RGD
Official Full Name
diacylglycerol kinase, deltaprovided by RGD
Primary source
RGD:1563309
See related
EnsemblRapid:ENSRNOG00000023238 AllianceGenome:RGD:1563309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563309
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity; kinase binding activity; and protein dimerization activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and regulation of signal transduction. Predicted to be located in clathrin-coated pit; cytoplasmic vesicle; and cytosol. Predicted to be active in plasma membrane. Orthologous to human DGKD (diacylglycerol kinase delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 137.8), Thymus (RPKM 137.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dgkd in Genome Data Viewer
Location:
9q35
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95964507..96055160)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88516686..88607349)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94980328..95071531)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene autophagy related 16-like 1 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene S-antigen visual arrestin Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glycosyltransferase 1 family, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. Harada BT, et al. Structure, 2008 Mar. PMID 18334213
  2. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. Sakane F, et al. J Biol Chem, 2002 Nov 8. PMID 12200442
  3. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Chibalin AV, et al. Cell, 2008 Feb 8. PMID 18267070
  4. Identification and characterization of two splice variants of human diacylglycerol kinase eta. Murakami T, et al. J Biol Chem, 2003 Sep 5. PMID 12810723
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In diabetic animals, reduced DGKdelta protein and DGK kinase activity were restored upon correction of glycemia.
    Title: Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in diacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phospholipase C/protein kinase C signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phospholipase C/protein kinase C signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
diacylglycerol kinase delta
NP_001414381.1
XP_017452342.2
XP_038940652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427452.1 → NP_001414381.1  diacylglycerol kinase delta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000112310.1, ENSRNOT00000155978.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    95964507..96055160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084724.2 → XP_038940652.1  diacylglycerol kinase delta isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6A9
    Related
    ENSRNOP00000109505.1, ENSRNOT00000160943.1
    Conserved Domains (5) summary
    smart00045
    Location:765 → 922
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323 → 445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd13274
    Location:55 → 151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    cd20893
    Location:231 → 291
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cl00040
    Location:140 → 224
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_017596853.3 → XP_017452342.2  diacylglycerol kinase delta isoform X2

    UniProtKB/TrEMBL
    A6JQE1
    Conserved Domains (5) summary
    cd09575
    Location:1014 → 1078
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:632 → 789
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190 → 312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20893
    Location:98 → 158
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cl00040
    Location:7 → 91
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
Nucleotide Protein Strain
Heading Accession and Version

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