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ypel3 yippee-like 3 [ Danio rerio (zebrafish) ]

Gene ID: 368214, updated on 4-Jan-2025

Summary

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Official Symbol
ypel3provided by ZNC
Official Full Name
yippee-like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030516-4
See related
Ensembl:ENSDARG00000055510 AllianceGenome:ZFIN:ZDB-GENE-030516-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Ypel1; cb475; wu:fi27c07
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within brain development; filopodium assembly; and glial cell differentiation. Predicted to be located in nucleolus. Is expressed in several structures, including central nervous system; pronephric duct; tail bud; ventral mesoderm; and yolk syncytial layer. Orthologous to human YPEL3 (yippee like 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ypel3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26186153..26191637, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26055282..26060766, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene si:ch211-11k18.4 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3a Neighboring gene mitogen-activated protein kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. Blanco-Sánchez B, et al. PLoS Genet, 2020 Jun. PMID 32544203, Free PMC Article
  2. Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Li C, et al. Gene, 2024 Apr 5. PMID 38242380
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  4. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon JM, et al. Hum Mol Genet, 2017 Oct 1. PMID 28934389, Free PMC Article
  5. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Lu X, et al. Cell Discov, 2015. PMID 27462426, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.
    Title: yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein yippee-like 3
Names
proteim yippee-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212790.1 → NP_997955.1  protein yippee-like 3

    See identical proteins and their annotated locations for NP_997955.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067578
    UniProtKB/Swiss-Prot
    Q6NWI4
    Related
    ENSDARP00000099958.3, ENSDART00000113843.5
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    26186153..26191637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NWI4.1 GenPept UniProtKB/Swiss-Prot:Q6NWI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.