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CG7997 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36829, updated on 4-Jan-2025

Summary

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Official Symbol
CG7997provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034117
Locus tag
Dmel_CG7997
See related
AllianceGenome:FB:FBgn0034117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT24026; Dmel\CG7997
Summary
Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; epithelium; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in Fabry disease; Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to several human genes including NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG7997 in Genome Data Viewer
Location:
53C1-53C1; 2-80 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16341251..16344182, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12228756..12231687, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 44kD subunit Neighboring gene HMG Coenzyme A synthase Neighboring gene Nucleoporin 62kD Neighboring gene wicked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Okumura T, et al. Gene Expr Patterns, 2007 Jan. PMID 16914392
  2. GATA factor genes in the Drosophila midgut embryo. Hernández de Madrid B, et al. PLoS One, 2018. PMID 29518114, Free PMC Article
  3. Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. Tian A, et al. PLoS Genet, 2017 Jul. PMID 28708826, Free PMC Article
  4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
  5. Proteomics in Drosophila melanogaster: first 2D database of larval hemolymph proteins. Vierstraete E, et al. Biochem Biophys Res Commun, 2003 May 16. PMID 12727233

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7997-PA
CG7997-PB
NP_611119.1
NP_725571.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16341251..16344182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166170.3 → NP_725571.1  uncharacterized protein Dmel_CG7997, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K127
    Related
    FBpp0086315
    Conserved Domains (1) summary
    cl07893
    Location:31 → 408
    AmyAc_family; Alpha amylase catalytic domain family

  2. NM_137275.4 → NP_611119.1  uncharacterized protein Dmel_CG7997, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611119.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K127
    Related
    FBpp0086316
    Conserved Domains (1) summary
    cl07893
    Location:31 → 408
    AmyAc_family; Alpha amylase catalytic domain family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K127 Q7K127

Gene LinkOut

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