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wcd wicked [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36831, updated on 9-Dec-2024

Summary

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Official Symbol
wcdprovided by FlyBase
Official Full Name
wickedprovided by FlyBase
Primary source
FLYBASE:FBgn0262560
Locus tag
Dmel_CG7989
See related
AllianceGenome:FB:FBgn0262560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7989; Dmel\CG7989; l(2)k07824; l(2)kO7824; Wcd
Summary
Involved in female germ-line stem cell asymmetric division; neuroblast proliferation; and rRNA processing. Located in germinal vesicle and nucleolus. Part of small nuclear ribonucleoprotein complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and visceral muscle primordium. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See wcd in Genome Data Viewer
Location:
53C1-53C1; 2-80 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16345838..16347500, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12233343..12235005, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of stage-specific germ cells using FACS in Drosophila germarium. Vallés AM, et al. Methods Cell Biol, 2020. PMID 32423645
  2. Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Fichelson P, et al. Nat Cell Biol, 2009 Jun. PMID 19430468
  3. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
  4. Large clusters of co-expressed genes in the Drosophila genome. Boutanaev AM, et al. Nature, 2002 Dec 12. PMID 12478293
  5. A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis. Jagut M, et al. G3 (Bethesda), 2013 Mar. PMID 23450845, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in female germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in germinal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small nuclear ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
wicked
Names
CG7989-PA
lethal (2) k07824
wcd-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16345838..16347500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137277.4 → NP_611121.1  wicked [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611121.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V7P1
    Related
    FBpp0086314
    Conserved Domains (3) summary
    COG2319
    Location:131 → 444
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:298 → 332
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:296 → 504
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V7P1.1 Q9V7P1

Gene LinkOut

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Chemical Information
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