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loopin-1 loopin-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36847, updated on 27-Dec-2024

Summary

Official Symbol
loopin-1provided by FlyBase
Official Full Name
loopin-1provided by FlyBase
Primary source
FLYBASE:FBgn0259795
Locus tag
Dmel_CG4750
See related
AllianceGenome:FB:FBgn0259795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.81; CG4750; Dmel\CG4750; FBgn0259795; kl3 lp-1; kl3lp1; loopin; S-LAP 6; S-Lap6
Summary
Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in major mitochondrial derivative. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See loopin-1 in Genome Data Viewer
Location:
53C7-53C7; 2-80 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16534943..16537086)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12422448..12424591)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene knotted onions Neighboring gene Semaphorin 2a Neighboring gene Syntrophin-like 2 Neighboring gene Dopamine transporter

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables metalloaminopeptidase activity IKR
Inferred from Key Residues
more info
PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in major mitochondrial derivative ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
loopin-1
Names
CG4750-PA
CG4750-PC
Sperm-LeucylAminoPeptidase 6
kl-3 loop protein-1
loopin-1-PA
loopin-1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16534943..16537086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103868.2NP_001097338.1  loopin-1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097338.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2S9
    Conserved Domains (2) summary
    PRK00913
    Location:43519
    PRK00913; multifunctional aminopeptidase A; Provisional
    cd00433
    Location:41518
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
  2. NM_137290.4NP_611134.1  loopin-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2S9
    Related
    FBpp0086239
    Conserved Domains (2) summary
    PRK00913
    Location:43519
    PRK00913; multifunctional aminopeptidase A; Provisional
    cd00433
    Location:41518
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...