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Lst Limostatin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36853, updated on 9-Dec-2024

Summary

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Official Symbol
Lstprovided by FlyBase
Official Full Name
Limostatinprovided by FlyBase
Primary source
FLYBASE:FBgn0034140
Locus tag
Dmel_CG8317
See related
AllianceGenome:FB:FBgn0034140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8317; Dmel\CG8317; lst
Summary
Involved in several processes, including glucose homeostasis; negative regulation of peptide hormone secretion; and triglyceride homeostasis. Is expressed in corpus cardiacum. Used to study obesity. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lst in Genome Data Viewer
Location:
53C8-53C8; 2-80 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16574579..16576586, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12462084..12464091, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S15 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44375 Neighboring gene Cyclin-dependent kinase 4 Neighboring gene Ribosomal protein LP2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster Limostatin and Its Human Ortholog Promote West Nile Virus Infection. Mead EB, et al. Insects, 2024 Jun 12. PMID 38921161, Free PMC Article
  2. Suppression of insulin production and secretion by a decretin hormone. Alfa RW, et al. Cell Metab, 2015 Feb 3. PMID 25651184, Free PMC Article
  3. Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila. Meschi E, et al. Neuron, 2024 Jul 17. PMID 38795709
  4. Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster. Chng WA, et al. Trends Endocrinol Metab, 2017 Feb. PMID 27923532
  5. Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila. Kim SK, et al. Cell Metab, 2021 Jul 6. PMID 34139200, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellular response to carbohydrate stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
limostatin
Names
CG8317-PA
CG8317-PB
CG8317-PC
Lst-PA
Lst-PB
Lst-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16574579..16576586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137294.3 → NP_611138.2  limostatin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611138.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NPB2
    Related
    FBpp0086268

  2. NM_001259439.2 → NP_001246368.1  limostatin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246368.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K762

  3. NM_001259440.2 → NP_001246369.1  limostatin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7D0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K762 A0A0B4K762
A0A0B4K7D0 A0A0B4K7D0
Q6NPB2 Q6NPB2

Gene LinkOut

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