Cdk4 Cyclin-dependent kinase 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk4provided by FlyBase
Official Full Name: Cyclin-dependent kinase 4provided by FlyBase
Primary source: FLYBASE:FBgn0016131
Locus tag: Dmel_CG5072
See related: AllianceGenome:FB:FBgn0016131
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 8-6; cdk; cdk4; CDK4; cdk4/6; Cdk4/6; CDK4/6; CG5072; dCdk4; DmCdk4; Dmel\CG5072; l(2)05428; l(2)0671; l(2)k06503; l(2)s4639; l(2)sh0671; Pk53C; Pk?7
Summary: Enables cyclin binding activity. Involved in several processes, including positive regulation of cell growth; positive regulation of signal transduction; and regulation of mitochondrion organization. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including familial melanoma; high grade glioma (multiple); pancreatic carcinoma (multiple); primary autosomal recessive microcephaly 12; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 53C9-53C9; 2-80 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16579470..16585448)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12466975..12472953)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altering the expression of the activating subunit of the Cdk5 protein kinase (Cdk5alpha) causes severe disruption of autophagy.
Title: Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5.
The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.
Title: Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.
CDK4 activity regulates mitobiogenesis by the activation of NRF-1 and consequent induction of Tfam and mitochondrial ribossomal transcription.
Title: Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress.
Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
Title: Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
mRpL12 is required for CycD/Cdk4-induced cell growth
Title: The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.
Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos
Title: Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos.
Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.
Title: Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrion organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclin-dependent kinase 4

Names: CG5072-PA; CG5072-PB; CG5072-PC; CG5072-PD; CG5072-PE; Cdk4-PA; Cdk4-PB; Cdk4-PC; Cdk4-PD; Cdk4-PE; Cyclin-dependent kinase 4/6; cyclin-dependent kinase 4; protein kinase-like 53C

NP_001286493.1

EC 2.7.11.22

NP_001286494.1

EC 2.7.11.22

NP_477196.1

EC 2.7.11.22

NP_725594.1

EC 2.7.11.22

NP_725595.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16579470..16585448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166185.2 → NP_725595.1 Cyclin-dependent kinase 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725595.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K306, Q94877

Related

FBpp0086249

Conserved Domains (2) summary

smart00220
Location:26 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07838
Location:26 → 312

STKc_CDK4_6_like; Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases
NM_166184.2 → NP_725594.1 Cyclin-dependent kinase 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725594.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K306, Q94877

Related

FBpp0086250

Conserved Domains (2) summary

smart00220
Location:26 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07838
Location:26 → 312

STKc_CDK4_6_like; Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases
NM_001299565.1 → NP_001286494.1 Cyclin-dependent kinase 4, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286494.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K306, Q94877

Conserved Domains (2) summary

smart00220
Location:26 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07838
Location:26 → 312

STKc_CDK4_6_like; Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases
NM_057848.3 → NP_477196.1 Cyclin-dependent kinase 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477196.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K306, Q94877

Related

FBpp0086251

Conserved Domains (2) summary

smart00220
Location:26 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07838
Location:26 → 312

STKc_CDK4_6_like; Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases
NM_001299564.1 → NP_001286493.1 Cyclin-dependent kinase 4, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286493.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K306, Q94877

Conserved Domains (2) summary

smart00220
Location:26 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07838
Location:26 → 312

STKc_CDK4_6_like; Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases