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Idgf6 Imaginal disc growth factor 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36868, updated on 9-Dec-2024

Summary

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Official Symbol
Idgf6provided by FlyBase
Official Full Name
Imaginal disc growth factor 6provided by FlyBase
Primary source
FLYBASE:FBgn0013763
Locus tag
Dmel_CG5210
See related
AllianceGenome:FB:FBgn0013763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5210; chit; Chit; Chit13; Cht13; DmDS47; Dmel\CG5210; DmIDGF6; ds47; DS47; idgf6
Summary
Enables chitin binding activity. Involved in several processes, including ecdysis, chitin-based cuticle; regulation of chitin metabolic process; and regulation of tube architecture, open tracheal system. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Idgf6 in Genome Data Viewer
Location:
53D2-53D2; 2-80 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16691022..16693751)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12578527..12581256)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 9 Neighboring gene long non-coding RNA:CR43104 Neighboring gene long non-coding RNA:CR44464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages. Kirkpatrick RB, et al. Gene, 1995 Feb 14. PMID 7875581
  2. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells. Kawamura K, et al. Development, 1999 Jan. PMID 9847235
  3. Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response. Sustar AE, et al. Genetics, 2023 Feb 9. PMID 36576887, Free PMC Article
  4. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
  5. Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster. Zimmerman SG, et al. Genetics, 2017 Jun. PMID 28404605, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables chitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables chitinase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables imaginal disc growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of chitin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube architecture, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
imaginal disc growth factor 6
Names
CG5210-PA
CG5210-PB
Idgf6-PA
Idgf6-PB
chitinase-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16691022..16693751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299570.1 → NP_001286499.1  imaginal disc growth factor 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286499.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2RVC8, E1UIC7, E1UIC9, E1UID0, E1UID3, E1UID4, Q23997, Q9V7S9
    UniProtKB/TrEMBL
    A0A0B4LFJ1
    Conserved Domains (2) summary
    cd02873
    Location:30 → 450
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:31 → 429
    Glyco_18; Glyco_18 domain

  2. NM_057733.4 → NP_477081.1  imaginal disc growth factor 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2RVC8, E1UIC7, E1UIC9, E1UID0, E1UID3, E1UID4, Q23997, Q9V7S9
    UniProtKB/TrEMBL
    A0A0B4LFJ1
    Related
    FBpp0086257
    Conserved Domains (2) summary
    cd02873
    Location:30 → 450
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:31 → 429
    Glyco_18; Glyco_18 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFJ1 A0A0B4LFJ1
Q23997.2 Q23997

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